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Tumor Expression of the Carcinoembryonic Antigen Correlates with High Mitotic Activity and Cell Pleomorphism Index in Lung Carcinoma
Joint Authors
Calzado, Enrique Rengifo
Cedeño, Mercedes
Ramos-Suzarte, Mayra
Rengifo, Charles E.
Blanco, Rancés
Frómeta, Milagros
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-05-29
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
At present, some research efforts are focusing on the evaluation of a variety of tumor associated antigens (TAAs) for a better understanding of tumor biology and genetics of lung tumors.
For this reason, we evaluated the tissue expression of carcinoembryonic antigen (CEA) and ior C2 (a cell surface O-linked glycoprotein carbohydrate chain TAA) in lung carcinomas, as well as its correlation with a variety of clinicopathological features.
The tissue expression of CEA was evidenced in 22/43 (51.16%) lung carcinomas and it was correlated with mitotic activity, cell pleomorphism indexes, and age of patients.
The expression of ior C2 was observed in 15/43 (34.88%) tumors but no correlation with the clinicopathological features mentioned above was obtained.
No correlation between both CEA and ior C2 antigens expression and the overall survival (OS) of non-small-cell lung cancer patients was also observed.
However, CEA-negative patients displayed higher OS rates as compared with positive ones (69.74 versus 58.26 months).
Our results seem to be in agreement with the role of CEA expression in tumor cell proliferation, inhibition of cell polarizations and tissue architecture distortion.
The significance of ior C2 antigen in these malignancies and it potential use in diagnosis, prognosis, and/or immunotherapy must be reevaluated.
American Psychological Association (APA)
Blanco, Rancés& Rengifo, Charles E.& Cedeño, Mercedes& Frómeta, Milagros& Calzado, Enrique Rengifo& Ramos-Suzarte, Mayra. 2013. Tumor Expression of the Carcinoembryonic Antigen Correlates with High Mitotic Activity and Cell Pleomorphism Index in Lung Carcinoma. Journal of Histology،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-501286
Modern Language Association (MLA)
Blanco, Rancés…[et al.]. Tumor Expression of the Carcinoembryonic Antigen Correlates with High Mitotic Activity and Cell Pleomorphism Index in Lung Carcinoma. Journal of Histology No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-501286
American Medical Association (AMA)
Blanco, Rancés& Rengifo, Charles E.& Cedeño, Mercedes& Frómeta, Milagros& Calzado, Enrique Rengifo& Ramos-Suzarte, Mayra. Tumor Expression of the Carcinoembryonic Antigen Correlates with High Mitotic Activity and Cell Pleomorphism Index in Lung Carcinoma. Journal of Histology. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-501286
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-501286