Genetic Variation in CYP17A1 Is Associated with Arterial Stiffness in Diabetic Subjects
Joint Authors
Kim, Jong-Won
Park, Se Eun
Yang, Soo Jin
Lee, Seung-Tae
Kim, Won Jun
Park, Sung Woo
Park, Cheol-Young
Source
Experimental Diabetes Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-23
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Hypertension and arterial stiffness are associated with an increasing risk of diabetes and cardiovascular diseases.
This study aimed to identify genetic variants affecting hypertension and arterial stiffness in diabetic subjects and to compare genetic associations with hypertension between prediabetic and diabetic subjects.
A total of 1,069 participants (326 prediabetic and 743 diabetic subjects) were assessed to determine the genetic variants affecting hypertension by analyzing 52 SNPs previously reported to be associated with hypertension.
Moreover, the SNPs were tested for association with hemodynamic parameters related to hypertension.
Out of the 52 SNPs analyzed, four SNPs including rs5326 (DRD1), rs1004467 (CYP17A1), rs2960306 (GRK4), and rs11191548 (near NT5C2) in diabetic subjects and rs1530440 (C10orf107) in prediabetic subjects showed a modest association with hypertension (P=0.0265, 0.0020, 0.0066, 0.0078, and 0.0015, resp; all were insignificant after Bonferroni correction).
Of these SNPs, rs1004467 in CYP17A1 was significantly associated with augmentation index in diabetic subjects who were not taking antihypertensive medication (P=0.0001; corrected P=0.006) but not in diabetic subjects receiving antihypertensive medication.
This finding suggests that certain genetic variations found in diabetic subjects may confer arterial stiffness and the development of hypertension and also be affected by antihypertensive medication.
American Psychological Association (APA)
Yang, Soo Jin& Lee, Seung-Tae& Kim, Won Jun& Park, Se Eun& Park, Sung Woo& Kim, Jong-Won…[et al.]. 2012. Genetic Variation in CYP17A1 Is Associated with Arterial Stiffness in Diabetic Subjects. Experimental Diabetes Research،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-501296
Modern Language Association (MLA)
Yang, Soo Jin…[et al.]. Genetic Variation in CYP17A1 Is Associated with Arterial Stiffness in Diabetic Subjects. Experimental Diabetes Research No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-501296
American Medical Association (AMA)
Yang, Soo Jin& Lee, Seung-Tae& Kim, Won Jun& Park, Se Eun& Park, Sung Woo& Kim, Jong-Won…[et al.]. Genetic Variation in CYP17A1 Is Associated with Arterial Stiffness in Diabetic Subjects. Experimental Diabetes Research. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-501296
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-501296