Evaluation on Anti-Inflammatory, Analgesic, Antitumor, and Antioxidant Potential of Total Saponins from Nigella glandulifera Seeds
Joint Authors
Zhao, Jun
Tan, Wei
Huang, Hua
Chen, Yan
Li, Chenyang
He, Jinhua
Wang, Linlin
Xu, Fang
Gu, Zhengyi
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-02-20
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Nigella glandulifera seeds are used as a spice or remedy for the treatment of various inflammatory diseases.
This study aimed to investigate analgesic (writhing test), anti-inflammatory (ear-induced edema, vascular permeability test), antioxidant, and antitumor activities of total saponins from this plant (TSN).
TSN (6, 12, and 24 mg/kg) were exhibited analgesic and anti-inflammatory activities in a dose-dependent manner (P<0.05).
In D-galactose-induced ageing model, TSN significantly increased the plasma superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities (P<0.05) and decreased the malondialdehyde (MDA) level compared to control group (P<0.05).
DPPH radical scavenging effect of TSN was also found.
Moreover, TSN (20 mg/mL) showed 86.75% and 88.26% inhibition of the growth on Bel-7402 and Hela cells, respectively.
Five compounds were further isolated and identified from TSN as Nigella A, B, C, D, and nigeglanoside, of which the content of Nigella A was 60.36±1.25 g/100 g TSN by HPLC-ELSD method.
Altogether, these results suggest that TSN could be considered as a potential analgesic, anti-inflammatory, antitumor, and antioxidant agent.
American Psychological Association (APA)
Zhao, Jun& Xu, Fang& Huang, Hua& Gu, Zhengyi& Wang, Linlin& Tan, Wei…[et al.]. 2013. Evaluation on Anti-Inflammatory, Analgesic, Antitumor, and Antioxidant Potential of Total Saponins from Nigella glandulifera Seeds. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-501302
Modern Language Association (MLA)
Zhao, Jun…[et al.]. Evaluation on Anti-Inflammatory, Analgesic, Antitumor, and Antioxidant Potential of Total Saponins from Nigella glandulifera Seeds. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-501302
American Medical Association (AMA)
Zhao, Jun& Xu, Fang& Huang, Hua& Gu, Zhengyi& Wang, Linlin& Tan, Wei…[et al.]. Evaluation on Anti-Inflammatory, Analgesic, Antitumor, and Antioxidant Potential of Total Saponins from Nigella glandulifera Seeds. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-501302
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-501302