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B Lymphocytes : Development, Tolerance, and Their Role in Autoimmunity—Focus on Systemic Lupus Erythematosus
Joint Authors
Cañas, Carlos Alberto
Izquierdo, Jorge H.
Tobón, Gabriel J.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-26
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
B lymphocytes are the effectors of humoral immunity, providing defense against pathogens through different functions including antibody production.
B cells constitute approximately 15% of peripheral blood leukocytes and arise from hemopoietic stem cells in the bone marrow.
It is here that their antigen receptors (surface immunoglobulin) are assembled.
In the context of autoimmune diseases defined by B and/or T cell autoreactive that upon activation lead to chronic tissue inflammation and often irreversible structural and functional damage, B lymphocytes play an essential role by not only producing autoantibodies but also functioning as antigen-presenting cells (APC) and as a source of cytokines.
In this paper, we describe B lymphocyte functions in autoimmunity and autoimmune diseases with a special focus on their abnormalities in systemic lupus erythematosus.
American Psychological Association (APA)
Tobón, Gabriel J.& Izquierdo, Jorge H.& Cañas, Carlos Alberto. 2013. B Lymphocytes : Development, Tolerance, and Their Role in Autoimmunity—Focus on Systemic Lupus Erythematosus. Autoimmune Diseases،Vol. 2013, no. 2013, pp.1-17.
https://search.emarefa.net/detail/BIM-501309
Modern Language Association (MLA)
Tobón, Gabriel J.…[et al.]. B Lymphocytes : Development, Tolerance, and Their Role in Autoimmunity—Focus on Systemic Lupus Erythematosus. Autoimmune Diseases No. 2013 (2013), pp.1-17.
https://search.emarefa.net/detail/BIM-501309
American Medical Association (AMA)
Tobón, Gabriel J.& Izquierdo, Jorge H.& Cañas, Carlos Alberto. B Lymphocytes : Development, Tolerance, and Their Role in Autoimmunity—Focus on Systemic Lupus Erythematosus. Autoimmune Diseases. 2013. Vol. 2013, no. 2013, pp.1-17.
https://search.emarefa.net/detail/BIM-501309
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-501309