B Lymphocytes : Development, Tolerance, and Their Role in Autoimmunity—Focus on Systemic Lupus Erythematosus

Joint Authors

Cañas, Carlos Alberto
Izquierdo, Jorge H.
Tobón, Gabriel J.

Source

Autoimmune Diseases

Issue

Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-17, 17 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2013-09-26

Country of Publication

Egypt

No. of Pages

17

Main Subjects

Diseases

Abstract EN

B lymphocytes are the effectors of humoral immunity, providing defense against pathogens through different functions including antibody production.

B cells constitute approximately 15% of peripheral blood leukocytes and arise from hemopoietic stem cells in the bone marrow.

It is here that their antigen receptors (surface immunoglobulin) are assembled.

In the context of autoimmune diseases defined by B and/or T cell autoreactive that upon activation lead to chronic tissue inflammation and often irreversible structural and functional damage, B lymphocytes play an essential role by not only producing autoantibodies but also functioning as antigen-presenting cells (APC) and as a source of cytokines.

In this paper, we describe B lymphocyte functions in autoimmunity and autoimmune diseases with a special focus on their abnormalities in systemic lupus erythematosus.

American Psychological Association (APA)

Tobón, Gabriel J.& Izquierdo, Jorge H.& Cañas, Carlos Alberto. 2013. B Lymphocytes : Development, Tolerance, and Their Role in Autoimmunity—Focus on Systemic Lupus Erythematosus. Autoimmune Diseases،Vol. 2013, no. 2013, pp.1-17.
https://search.emarefa.net/detail/BIM-501309

Modern Language Association (MLA)

Tobón, Gabriel J.…[et al.]. B Lymphocytes : Development, Tolerance, and Their Role in Autoimmunity—Focus on Systemic Lupus Erythematosus. Autoimmune Diseases No. 2013 (2013), pp.1-17.
https://search.emarefa.net/detail/BIM-501309

American Medical Association (AMA)

Tobón, Gabriel J.& Izquierdo, Jorge H.& Cañas, Carlos Alberto. B Lymphocytes : Development, Tolerance, and Their Role in Autoimmunity—Focus on Systemic Lupus Erythematosus. Autoimmune Diseases. 2013. Vol. 2013, no. 2013, pp.1-17.
https://search.emarefa.net/detail/BIM-501309

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-501309