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Tetrahydrocannabinol (Delta 9-THC) Treatment in Chronic Central Neuropathic Pain and Fibromyalgia Patients : Results of a Multicenter Survey
Joint Authors
Ueberall, Michael
Gerber, Helmut
Schleinzer, Wolfgang
Schuepfer, Guido
Rukwied, Roman
Casutt, Matthias
Schley, Marcus
Weber, Janet
Konrad, Christoph
Source
Anesthesiology Research and Practice
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-11-23
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Central neuropathic pain is difficult to treat, but delta 9-Tetrahydrocannabinol (delta 9-THC) may be a promising therapeutic agent.
We administered in 172 patients on average 7.5 mg delta 9-THC over 7 months.
Of these, 48 patients prematurely withdrew due to side effects, insufficient analgesia, or expense of therapy.
Thus, 124 patients were assessed retrospectively in a multicenter telephone survey.
Reported changes in pain intensity, recorded on a numeric rating scale (NRS), Pain Disability Index (PDI), Medical Outcomes Short-Form (SF-12), Quality of Life Impairment by Pain (QLIP), Hospital Anxiety Depression Scale (HADS), and amount of concomitant pain medication were recorded.
Psychometric parameters (PDI, SF-12, QLIP, HADS) and pain intensity improved significantly during delta 9-THC treatment.
Opioid doses were reduced and patients perceived THC therapy as effective with tolerable side effects.
About 25% of the patients, however, did not tolerate the treatment.
Therapy success and tolerance can be assessed by a transient delta 9-THC titration and its maintained administration for several weeks.
The present survey demonstrates its ameliorating potential for the treatment of chronic pain in central neuropathy and fibromyalgia.
A supplemental delta 9-THC treatment as part of a broader pain management plan therefore may represent a promising coanalgesic therapeutic option.
American Psychological Association (APA)
Weber, Janet& Schley, Marcus& Casutt, Matthias& Gerber, Helmut& Schuepfer, Guido& Rukwied, Roman…[et al.]. 2009. Tetrahydrocannabinol (Delta 9-THC) Treatment in Chronic Central Neuropathic Pain and Fibromyalgia Patients : Results of a Multicenter Survey. Anesthesiology Research and Practice،Vol. 2009, no. 2009, pp.1-9.
https://search.emarefa.net/detail/BIM-501314
Modern Language Association (MLA)
Weber, Janet…[et al.]. Tetrahydrocannabinol (Delta 9-THC) Treatment in Chronic Central Neuropathic Pain and Fibromyalgia Patients : Results of a Multicenter Survey. Anesthesiology Research and Practice No. 2009 (2009), pp.1-9.
https://search.emarefa.net/detail/BIM-501314
American Medical Association (AMA)
Weber, Janet& Schley, Marcus& Casutt, Matthias& Gerber, Helmut& Schuepfer, Guido& Rukwied, Roman…[et al.]. Tetrahydrocannabinol (Delta 9-THC) Treatment in Chronic Central Neuropathic Pain and Fibromyalgia Patients : Results of a Multicenter Survey. Anesthesiology Research and Practice. 2009. Vol. 2009, no. 2009, pp.1-9.
https://search.emarefa.net/detail/BIM-501314
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-501314