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Hepatitis B Virus X Upregulates HuR Protein Level to Stabilize HER2 Expression in Hepatocellular Carcinoma Cells
Joint Authors
Lin, Chih-Wen
Ho, Chien-Yi
Hou, Pao-Sheng
Huang, Wei-Chien
Chien, Yu-Fong
Chen, Jhen-Yu
Hung, Chao-Ming
Chien, Pei-Hsuan
Pan, Hsiao-Lin
Leow, Kar-Hee
Chen, Lei-Chin
Lin, Ching-Chiao
Chen, Wen-Shu
Chien, Pei-Hsuan
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-27
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Hepatitis B virus- (HBV-) associated hepatocellular carcinoma (HCC) is the most common type of liver cancer.
However, the underlying mechanism of HCC tumorigenesis is very complicated and HBV-encoded X protein (HBx) has been reported to play the most important role in this process.
Activation of downstream signal pathways of epidermal growth factor receptor (EGFR) family is known to mediate HBx-dependent HCC tumor progression.
Interestingly, HER2 (also known as ErbB2/Neu/EGFR2) is frequently overexpressed in HBx-expressing HCC patients and is associated with their poor prognosis.
However, it remains unclear whether and how HBx regulates HER2 expression.
In this study, our data showed that HBx expression increased HER2 protein level via enhancing its mRNA stability.
The induction of RNA-binding protein HuR expression by HBx mediated the HER2 mRNA stabilization.
Finally, the upregulated HER2 expression promoted the migration ability of HBx-expressing HCC cells.
These findings deciphered the molecular mechanism of HBx-mediated HER2 upregulation in HBV-associated HCC.
American Psychological Association (APA)
Hung, Chao-Ming& Huang, Wei-Chien& Pan, Hsiao-Lin& Chien, Pei-Hsuan& Lin, Chih-Wen& Chen, Lei-Chin…[et al.]. 2014. Hepatitis B Virus X Upregulates HuR Protein Level to Stabilize HER2 Expression in Hepatocellular Carcinoma Cells. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-501327
Modern Language Association (MLA)
Hung, Chao-Ming…[et al.]. Hepatitis B Virus X Upregulates HuR Protein Level to Stabilize HER2 Expression in Hepatocellular Carcinoma Cells. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-501327
American Medical Association (AMA)
Hung, Chao-Ming& Huang, Wei-Chien& Pan, Hsiao-Lin& Chien, Pei-Hsuan& Lin, Chih-Wen& Chen, Lei-Chin…[et al.]. Hepatitis B Virus X Upregulates HuR Protein Level to Stabilize HER2 Expression in Hepatocellular Carcinoma Cells. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-501327
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-501327