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Degree of Acute Kidney Injury before Dialysis Initiation and Hospital Mortality in Critically Ill Patients
Joint Authors
Almenoff, Peter
Render, Marta L.
Thakar, Charuhas V.
Christianson, Annette
Freyberg, Ron
Source
International Journal of Nephrology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-01-08
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
In a multicenter observational cohort of patients-admitted to intensive care units (ICU), we assessed whether creatinine elevation prior to dialysis initiation in acute kidney injury (AKI-D) further discriminates risk-adjusted mortality.
AKI-D was categorized into four groups (Grp) based on creatinine elevation after ICU admission but before dialysis initiation: Grp I > 0.3 mg/dL to <2-fold increase, Grp II ≥2 times but <3 times increase, Grp III ≥3-fold increase in creatinine, and Grp IV none or <0.3 mg/dl increase.
Standardized mortality rates (SMR) were calculated by using a validated risk-adjusted mortality model and expressed with 95% confidence intervals (CI).
2,744 patients developed AKI-D during ICU stay; 36.7%, 20.9%, 31.2%, and 11.2% belonged to groups I, II, III, and IV, respectively.
SMR showed a graded increase in Grp I, II, and III (1.40 (95% CI, 1.29–1.42), 1.84 (1.66–2.04), and 2.25 (2.07–2.45)) and was 0.98 (0.78–1.20) in Grp IV.
In ICU patients with AKI-D, degree of creatinine elevation prior to dialysis initiation is independently associated with hospital mortality.
It is the lowest in those experiencing minor or no elevations in creatinine and may represent reversible fluid-electrolyte disturbances.
American Psychological Association (APA)
Thakar, Charuhas V.& Christianson, Annette& Almenoff, Peter& Freyberg, Ron& Render, Marta L.. 2013. Degree of Acute Kidney Injury before Dialysis Initiation and Hospital Mortality in Critically Ill Patients. International Journal of Nephrology،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-501332
Modern Language Association (MLA)
Thakar, Charuhas V.…[et al.]. Degree of Acute Kidney Injury before Dialysis Initiation and Hospital Mortality in Critically Ill Patients. International Journal of Nephrology No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-501332
American Medical Association (AMA)
Thakar, Charuhas V.& Christianson, Annette& Almenoff, Peter& Freyberg, Ron& Render, Marta L.. Degree of Acute Kidney Injury before Dialysis Initiation and Hospital Mortality in Critically Ill Patients. International Journal of Nephrology. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-501332
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-501332