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DNA DamageRepair and Polymorphism of the hOGG1 Gene in Lymphocytes of AMD Patients
Joint Authors
Blasiak, Janusz
Janik-Papis, Katarzyna
Szaflik, Jerzy
Poplawski, Tomasz R.
Wozniak, Katarzyna
Sklodowska, Anna
Zaras, Malgorzata
Szaflik, Jacek P.
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-10-26
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Oxidative stress is thought to play a role in the pathogenesis of age-related macular degeneration (AMD).
We determined the extent of oxidative DNA damage and the kinetics of its removal as well as the genotypes of the Ser326Cys polymorphism of the hOGG1 gene in lymphocytes of 30 wet AMD patients and 30 controls.
Oxidative DNA damage induced by hydrogen peroxide and its repair were evaluated by the comet assay and DNA repair enzymes.
We observed a higher extent of endogenous oxidative DNA damage and a lower efficacy of its repair in AMD patients as compared with the controls.
We did not find any correlation between the extent of DNA damage and efficacy of DNA repair with genotypes of the Ser326Cys polymorphism.
The results obtained suggest that oxidative DNA damage and inefficient DNA repair can be associated with AMD and the variability of the hOOG1 gene may not contribute to this association.
American Psychological Association (APA)
Wozniak, Katarzyna& Szaflik, Jacek P.& Zaras, Malgorzata& Sklodowska, Anna& Janik-Papis, Katarzyna& Poplawski, Tomasz R.…[et al.]. 2009. DNA DamageRepair and Polymorphism of the hOGG1 Gene in Lymphocytes of AMD Patients. Journal of Biomedicine and Biotechnology،Vol. 2009, no. 2009, pp.1-9.
https://search.emarefa.net/detail/BIM-501348
Modern Language Association (MLA)
Wozniak, Katarzyna…[et al.]. DNA DamageRepair and Polymorphism of the hOGG1 Gene in Lymphocytes of AMD Patients. Journal of Biomedicine and Biotechnology No. 2009 (2009), pp.1-9.
https://search.emarefa.net/detail/BIM-501348
American Medical Association (AMA)
Wozniak, Katarzyna& Szaflik, Jacek P.& Zaras, Malgorzata& Sklodowska, Anna& Janik-Papis, Katarzyna& Poplawski, Tomasz R.…[et al.]. DNA DamageRepair and Polymorphism of the hOGG1 Gene in Lymphocytes of AMD Patients. Journal of Biomedicine and Biotechnology. 2009. Vol. 2009, no. 2009, pp.1-9.
https://search.emarefa.net/detail/BIM-501348
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-501348