Lobar Hepatocellular Carcinoma with Ipsilateral Portal Vein Tumor Thrombosis Treated with Yttrium-90 Glass Microsphere Radioembolization : Preliminary Results
Joint Authors
Audrain, Odile
Mesbah, H.
Clement, Bruno
Edeline, J.
Latournerie, M.
Garin, Etienne
Pracht, M.
Boucher, E.
Raoul, J. L.
Lenoir, L.
Rolland, Y.
Source
International Journal of Hepatology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-02-17
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Portal vein tumor thrombosis (PVTT) is a common complication of hepatocellular carcinoma (HCC) and has a negative impact on prognosis.
This characteristic feature led to the rationale of the present trial designed to assess the efficacy and the safety of yttrium-90 glass-microsphere treatment for advanced-stage lobar HCC with ipsilateral PVTT.
18 patients with unresectable lobar HCC and ipsilateral PVTT were treated in our institution with 90Y-microS radioembolization.
Patients were evaluated every 3 to 6 months for response, survival, and toxicity.
Mean follow-up was 13.0 months (2.2–50.6).
Outcomes were: complete response (n=2), partial response (n=13), stable disease (n=1), and progressive disease (n=2) giving a disease control rate of 88.9%.
Four patients were downstaged.
Treating lobar hepatocellular carcinoma with ipsilateral portal vein thrombosis with yttrium-90 glass-microsphere radioembolization is safe and efficacious.
Further clinical trials are warranted to confirm these results and to compare 90Y-microS with sorafenib, taking into account not only survival but also the possibility of secondary surgery for putative curative intention after downstaging.
American Psychological Association (APA)
Pracht, M.& Edeline, J.& Lenoir, L.& Latournerie, M.& Mesbah, H.& Audrain, Odile…[et al.]. 2013. Lobar Hepatocellular Carcinoma with Ipsilateral Portal Vein Tumor Thrombosis Treated with Yttrium-90 Glass Microsphere Radioembolization : Preliminary Results. International Journal of Hepatology،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-501357
Modern Language Association (MLA)
Pracht, M.…[et al.]. Lobar Hepatocellular Carcinoma with Ipsilateral Portal Vein Tumor Thrombosis Treated with Yttrium-90 Glass Microsphere Radioembolization : Preliminary Results. International Journal of Hepatology No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-501357
American Medical Association (AMA)
Pracht, M.& Edeline, J.& Lenoir, L.& Latournerie, M.& Mesbah, H.& Audrain, Odile…[et al.]. Lobar Hepatocellular Carcinoma with Ipsilateral Portal Vein Tumor Thrombosis Treated with Yttrium-90 Glass Microsphere Radioembolization : Preliminary Results. International Journal of Hepatology. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-501357
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-501357