Analysis of Nucleotide Variations in Genes of Iron Management in Patients of Parkinson's Disease and Other Movement Disorders
Joint Authors
Castiglioni, Emanuela
Pezzoli, Gianni
Poli, Maura
Forni, Gianluca
Maccarinelli, Federica
Arosio, Paolo
Girelli, Domenico
Goldwurm, Stefano
Finazzi, Dario
Ferrari, Maurizio
Cremonesi, Laura
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-10-17
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The capacity to act as an electron donor and acceptor makes iron an essential cofactor of many vital processes.
Its balance in the body has to be tightly regulated since its excess can be harmful by favouring oxidative damage, while its deficiency can impair fundamental activities like erythropoiesis.
In the brain, an accumulation of iron or an increase in its availability has been associated with the development and/or progression of different degenerative processes, including Parkinson's disease, while iron paucity seems to be associated with cognitive deficits, motor dysfunction, and restless legs syndrome.
In the search of DNA sequence variations affecting the individual predisposition to develop movement disorders, we scanned by DHPLC the exons and intronic boundary regions of ceruloplasmin, iron regulatory protein 2, hemopexin, hepcidin and hemojuvelin genes in cohorts of subjects affected by Parkinson's disease and idiopathic neurodegeneration with brain iron accumulation (NBIA).
Both novel and known sequence variations were identified in most of the genes, but none of them seemed to be significantly associated to the movement diseases of interest.
American Psychological Association (APA)
Castiglioni, Emanuela& Finazzi, Dario& Goldwurm, Stefano& Pezzoli, Gianni& Forni, Gianluca& Girelli, Domenico…[et al.]. 2010. Analysis of Nucleotide Variations in Genes of Iron Management in Patients of Parkinson's Disease and Other Movement Disorders. Conference Papers in Medicine،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-501362
Modern Language Association (MLA)
Castiglioni, Emanuela…[et al.]. Analysis of Nucleotide Variations in Genes of Iron Management in Patients of Parkinson's Disease and Other Movement Disorders. Conference Papers in Medicine No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-501362
American Medical Association (AMA)
Castiglioni, Emanuela& Finazzi, Dario& Goldwurm, Stefano& Pezzoli, Gianni& Forni, Gianluca& Girelli, Domenico…[et al.]. Analysis of Nucleotide Variations in Genes of Iron Management in Patients of Parkinson's Disease and Other Movement Disorders. Conference Papers in Medicine. 2010. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-501362
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-501362