Endoplasmic Reticulum Stress and Diabetic Cardiomyopathy
Joint Authors
Cai, Lu
Xu, Wei
Xu, Jiancheng
Zhou, Qi
Source
Experimental Diabetes Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-24
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The endoplasmic reticulum (ER) is an organelle entrusted with lipid synthesis, calcium homeostasis, protein folding, and maturation.
Perturbation of ER-associated functions results in an evolutionarily conserved cell stress response, the unfolded protein response (UPR) that is also called ER stress.
ER stress is aimed initially at compensating for damage but can eventually trigger cell death if ER stress is excessive or prolonged.
Now the ER stress has been associated with numerous diseases.
For instance, our recent studies have demonstrated the important role of ER stress in diabetes-induced cardiac cell death.
It is known that apoptosis has been considered to play a critical role in diabetic cardiomyopathy.
Therefore, this paper will summarize the information from the literature and our own studies to focus on the pathological role of ER stress in the development of diabetic cardiomyopathy.
Improved understanding of the molecular mechanisms underlying UPR activation and ER-initiated apoptosis in diabetic cardiomyopathy will provide us with new targets for drug discovery and therapeutic intervention.
American Psychological Association (APA)
Xu, Jiancheng& Zhou, Qi& Xu, Wei& Cai, Lu. 2011. Endoplasmic Reticulum Stress and Diabetic Cardiomyopathy. Experimental Diabetes Research،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-501382
Modern Language Association (MLA)
Xu, Jiancheng…[et al.]. Endoplasmic Reticulum Stress and Diabetic Cardiomyopathy. Experimental Diabetes Research No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-501382
American Medical Association (AMA)
Xu, Jiancheng& Zhou, Qi& Xu, Wei& Cai, Lu. Endoplasmic Reticulum Stress and Diabetic Cardiomyopathy. Experimental Diabetes Research. 2011. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-501382
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-501382