Cell Proliferation in Cutaneous Malignant Melanoma : Relationship with Neoplastic Progression

Author

Piérard, Gérald E.

Source

ISRN Dermatology

Issue

Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2012-01-11

Country of Publication

Egypt

No. of Pages

12

Main Subjects

Diseases

Abstract EN

The establishment of the diagnosis of cutaneous malignant melanoma (CMM) always calls for histopathological confirmation.

Further to the recognition of the CMM aspects, immunohistochemistry is helpful, in particular, in determining the size of the replicative compartment and the activity in each of the cell cycle phases (G1, S, G2, M).

The involvement of cancer stem cells and transient amplifier cells in CMM genesis is beyond doubt.

The proliferation activity is indicative of the neoplastic progression and is often related to the clinical growth rate of the neoplasm.

It allows to distinguish high-risk CMM commonly showing a high growth rate, from those CMMs of lower malignancy associated with a more limited growth rate.

The recruitment and progression of CMM cells in the cell cycle of proliferation depend on mitogen-activated protein kinase (MAPK) pathway and result from a loss of control normally involving a series of key regulatory cyclins.

In addition, the apoptotic pathways potentially counteracting any excess in proliferative activity are out of the dependency of specific regulatory molecular mechanisms.

Key molecular components involved in the deregulation of the growth fraction, the cell cycle phases of proliferation, and apoptosis are presently described in CMM.

American Psychological Association (APA)

Piérard, Gérald E.. 2012. Cell Proliferation in Cutaneous Malignant Melanoma : Relationship with Neoplastic Progression. ISRN Dermatology،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-501398

Modern Language Association (MLA)

Piérard, Gérald E.. Cell Proliferation in Cutaneous Malignant Melanoma : Relationship with Neoplastic Progression. ISRN Dermatology No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-501398

American Medical Association (AMA)

Piérard, Gérald E.. Cell Proliferation in Cutaneous Malignant Melanoma : Relationship with Neoplastic Progression. ISRN Dermatology. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-501398

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-501398