Cell Proliferation in Cutaneous Malignant Melanoma : Relationship with Neoplastic Progression
Author
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-01-11
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The establishment of the diagnosis of cutaneous malignant melanoma (CMM) always calls for histopathological confirmation.
Further to the recognition of the CMM aspects, immunohistochemistry is helpful, in particular, in determining the size of the replicative compartment and the activity in each of the cell cycle phases (G1, S, G2, M).
The involvement of cancer stem cells and transient amplifier cells in CMM genesis is beyond doubt.
The proliferation activity is indicative of the neoplastic progression and is often related to the clinical growth rate of the neoplasm.
It allows to distinguish high-risk CMM commonly showing a high growth rate, from those CMMs of lower malignancy associated with a more limited growth rate.
The recruitment and progression of CMM cells in the cell cycle of proliferation depend on mitogen-activated protein kinase (MAPK) pathway and result from a loss of control normally involving a series of key regulatory cyclins.
In addition, the apoptotic pathways potentially counteracting any excess in proliferative activity are out of the dependency of specific regulatory molecular mechanisms.
Key molecular components involved in the deregulation of the growth fraction, the cell cycle phases of proliferation, and apoptosis are presently described in CMM.
American Psychological Association (APA)
Piérard, Gérald E.. 2012. Cell Proliferation in Cutaneous Malignant Melanoma : Relationship with Neoplastic Progression. ISRN Dermatology،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-501398
Modern Language Association (MLA)
Piérard, Gérald E.. Cell Proliferation in Cutaneous Malignant Melanoma : Relationship with Neoplastic Progression. ISRN Dermatology No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-501398
American Medical Association (AMA)
Piérard, Gérald E.. Cell Proliferation in Cutaneous Malignant Melanoma : Relationship with Neoplastic Progression. ISRN Dermatology. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-501398
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-501398