Effect of Antimicrobial Peptide, Nisin, on the Reproductive Functions of Rats
Joint Authors
Gupta, S. M.
Reddy, K. V. R.
Aranha, C. C.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-01-11
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Our previous studies have demonstrated that naturally occurring peptide, Nisin possess antibacterial activity and did not interfere with rabbit vaginal mucosa.
In this study, the reproductive toxicity of the Nisin in male rats was evaluated.
Rats were fed orally with Nisin (10, 25, and 50 mg/kg/day) for 13 weeks.
No treatment related mortality was observed.
The body weight gain, food consumption and serum biochemical parameters were at par with the control group.
Histomorphology of the selected reproductive (testis, epididymis, ventral prostate, and seminal vesicle) and nonreproductive (liver and kidney) tissues was observed to be normal.
There was no treatment-related increase or decrease in the expression of testis-specific genes (c-Kit, GATA-1, and HILS-1) and the activity levels of epididymal α-glucosidase, ventral prostate alkaline phosphatase (AlP), liver alanine aminotransferase (AlAT) and aspartate aminotransferase (AAT).
Fructose and lactic acid levels in the seminal vesicles also remained unchanged.
These studies suggest that Nisin did not affect the normal physiology of these organs.
In addition, no adverse effects were observed on the reproductive performance of Nisin-treated male rats and their offspring.
In conclusion, the current studies support our earlier studies, which demonstrated suitability of Nisin as a safe and effective microbicide.
American Psychological Association (APA)
Reddy, K. V. R.& Gupta, S. M.& Aranha, C. C.. 2012. Effect of Antimicrobial Peptide, Nisin, on the Reproductive Functions of Rats. ISRN Veterinary Science،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-501437
Modern Language Association (MLA)
Reddy, K. V. R.…[et al.]. Effect of Antimicrobial Peptide, Nisin, on the Reproductive Functions of Rats. ISRN Veterinary Science No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-501437
American Medical Association (AMA)
Reddy, K. V. R.& Gupta, S. M.& Aranha, C. C.. Effect of Antimicrobial Peptide, Nisin, on the Reproductive Functions of Rats. ISRN Veterinary Science. 2012. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-501437
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-501437