Current Status of Poly(ADP-ribose) Polymerase Inhibitors as Novel Therapeutic Agents for Triple-Negative Breast Cancer
Joint Authors
Source
International Journal of Breast Cancer
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-25
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Triple-negative breast cancer (TNBC) is an aggressive type of breast cancer that is clinically defined as lacking estrogen and progesterone receptors, as well as being ERBB2 (HER-2) negative.
Without specific therapeutic targets, TNBC carries a worse prognosis than other types of breast cancer in the absence of therapy.
Research has now further differentiated breast cancer into subtypes based on genetic expression patterns.
One of these subtypes, basal-like, frequently overlaps with the clinical picture of TNBC.
Additionally, both TNBC and basal-like breast cancer link to BRCA mutations.
Recent pharmaceutical advances have created a class of drugs, poly(ADP-ribose) polymerase (PARP) inhibitors, which are showing potential to effectively treat these patients.
The aim of this paper is to summarize the basis behind PARP inhibitors and update the current status of their development in clinical trials for the treatment of TNBC.
American Psychological Association (APA)
Hiller, David J.& Chu, Quyen D.. 2011. Current Status of Poly(ADP-ribose) Polymerase Inhibitors as Novel Therapeutic Agents for Triple-Negative Breast Cancer. International Journal of Breast Cancer،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-501473
Modern Language Association (MLA)
Hiller, David J.& Chu, Quyen D.. Current Status of Poly(ADP-ribose) Polymerase Inhibitors as Novel Therapeutic Agents for Triple-Negative Breast Cancer. International Journal of Breast Cancer No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-501473
American Medical Association (AMA)
Hiller, David J.& Chu, Quyen D.. Current Status of Poly(ADP-ribose) Polymerase Inhibitors as Novel Therapeutic Agents for Triple-Negative Breast Cancer. International Journal of Breast Cancer. 2011. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-501473
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-501473