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Near Fatal Asthma : Clinical and Airway Biopsy Characteristics
Joint Authors
Arenas, Maggie
Papanikolaou, Ilias C.
Katagihara, Elton
Koss, Michael N.
Barbers, Richard G.
Azen, Colleen G.
Chan, Khalid
Sharma, Om P.
Patel, Ashish
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-09
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Inflammation and remodeling are integral parts of asthma pathophysiology.
We sought to describe the clinical and pathologic features of near fatal asthma exacerbation (NFE).
Methods.
Bronchial biopsies were collected prospectively from NFE I subjects.
Another NFE II group and a moderate severity exacerbation control group (ME II) were retrospectively identified—no biopsies obtained.
Results.
All NFE II (n=9) subjects exhibited remodeling and significant inflammation (eosinophilic, neutrophilic).
NFE II group (n=37) had a significant history of prior intubation and inhaled corticosteroids usage compared to ME II group (n=41).
They also exhibited leukocytosis, eosinophilia, and longer hospitalization days.
Conclusions.
Remodeling, eosinophilic, and neutrophilic inflammation were observed in NFE.
NFE is associated with prior intubation and inhaled corticosteroids usage.
American Psychological Association (APA)
Barbers, Richard G.& Papanikolaou, Ilias C.& Koss, Michael N.& Patel, Ashish& Katagihara, Elton& Arenas, Maggie…[et al.]. 2012. Near Fatal Asthma : Clinical and Airway Biopsy Characteristics. Pulmonary Medicine،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-501505
Modern Language Association (MLA)
Barbers, Richard G.…[et al.]. Near Fatal Asthma : Clinical and Airway Biopsy Characteristics. Pulmonary Medicine No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-501505
American Medical Association (AMA)
Barbers, Richard G.& Papanikolaou, Ilias C.& Koss, Michael N.& Patel, Ashish& Katagihara, Elton& Arenas, Maggie…[et al.]. Near Fatal Asthma : Clinical and Airway Biopsy Characteristics. Pulmonary Medicine. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-501505
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-501505