Angiotensin II, Aldosterone, and Anti-Inflammatory Lymphocytes : Interplay and Therapeutic Opportunities
Joint Authors
Kasal, Daniel Arthur B.
Schiffrin, Ernesto L.
Source
International Journal of Hypertension
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-21
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Inflammation is recognized as an important factor in the pathophysiology of hypertension, with the renin-angiotensin-aldosterone system (RAAS) playing a key role in the disease.
Initially described because of its contribution to extracellular fluid and electrolyte homeostasis, the RAAS has been implicated in endothelial dysfunction, vascular remodeling, oxidative stress, proinflammatory cytokine production, and adhesion molecule synthesis by the vascular wall.
Both angiotensin II and aldosterone are involved in these systemic effects, activating innate and adaptive immune responses.
This paper highlights some aspects connecting RAAS to the hypertensive phenotype, based on experimental and clinical studies, with emphasis on new findings regarding the contribution of an increasingly studied population of T lymphocytes: the T-regulatory lymphocytes.
These cells can suppress inflammation and may exert beneficial vascular effects in animal models of hypertension.Erratum to “Angiotensin II, Aldosterone, and Anti-Inflammatory Lymphocytes: Interplay and Therapeutic Opportunities”dx.doi.org/10.1155/2012/132598
American Psychological Association (APA)
Kasal, Daniel Arthur B.& Schiffrin, Ernesto L.. 2012. Angiotensin II, Aldosterone, and Anti-Inflammatory Lymphocytes : Interplay and Therapeutic Opportunities. International Journal of Hypertension،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-501521
Modern Language Association (MLA)
Kasal, Daniel Arthur B.& Schiffrin, Ernesto L.. Angiotensin II, Aldosterone, and Anti-Inflammatory Lymphocytes : Interplay and Therapeutic Opportunities. International Journal of Hypertension No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-501521
American Medical Association (AMA)
Kasal, Daniel Arthur B.& Schiffrin, Ernesto L.. Angiotensin II, Aldosterone, and Anti-Inflammatory Lymphocytes : Interplay and Therapeutic Opportunities. International Journal of Hypertension. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-501521
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-501521