Time Sensitivity Factor of Single Pulmonary Nodule : A New Cancer Characteristic Metabolic Parameter by F18-FDG PET
Joint Authors
Tyan, Yeu-Sheng
Lee, Chiang-Hsuan
Wang, Jhi-Joung
Cheng, Cheng-Yi
Lee, Kwo-Whei
Yang, Chao-Wei
Cheng, Ching-Yuan
Huang, Wen-Sheng
Oliver Wong, Ching-Yee
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-18
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Objective.
To calculate the time sensitivity factor (S) for discriminating the solitary pulmonary nodule (SPN) by FDG PET at different time points.
Methods.
The multiple time-point FDG PET images from 41 patients for evaluating SPN seen on chest X-ray or CT were prospectively analyzed to calculate and evaluate S against the gold standard of tissue histology (n=38) or long term clinicoradiographic follow-up (n=3).
The maximal standardized uptake values (SUV) at the 3 hourly time points were measured.
The S was calculated using S=d{ln(SUV)}/d{ln(t)} at 3 different time intervals.
ROC analysis of the S parameters was performed to evaluate the optimal cut-off value and their accuracy in classifying the SPN.
Results.
The SUV in malignant SPN was higher than the corresponding value in benign lesions at all 3 hourly time points (P<0.003).
The S parameters using 3 different time intervals all significantly separated the two groups (P<0.0005) with an optimal cut-off point near the theoretical value of zero with a high sensitivity of 100% and specificity of 86%.
Conclusion.
The S can be calculated for SPNs using multiple time-point FDG PET, providing a tumor characteristic metabolic parameter with high discrimination power using a simple positive value representing malignancy.
American Psychological Association (APA)
Cheng, Ching-Yuan& Lee, Kwo-Whei& Lee, Chiang-Hsuan& Tyan, Yeu-Sheng& Cheng, Cheng-Yi& Wang, Jhi-Joung…[et al.]. 2014. Time Sensitivity Factor of Single Pulmonary Nodule : A New Cancer Characteristic Metabolic Parameter by F18-FDG PET. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-501528
Modern Language Association (MLA)
Cheng, Ching-Yuan…[et al.]. Time Sensitivity Factor of Single Pulmonary Nodule : A New Cancer Characteristic Metabolic Parameter by F18-FDG PET. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-501528
American Medical Association (AMA)
Cheng, Ching-Yuan& Lee, Kwo-Whei& Lee, Chiang-Hsuan& Tyan, Yeu-Sheng& Cheng, Cheng-Yi& Wang, Jhi-Joung…[et al.]. Time Sensitivity Factor of Single Pulmonary Nodule : A New Cancer Characteristic Metabolic Parameter by F18-FDG PET. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-501528
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-501528