Cryptococcus neoformans as a Model for Radioimmunotherapy of Infections
Joint Authors
Casadevall, Arturo
Dadachova, Ekaterina
Source
Interdisciplinary Perspectives on Infectious Diseases
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-05-24
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
There is an obvious and urgent need for novel approaches to treat infectious diseases.
The use of monoclonal antibodies in therapy of infectious diseases is now experiencing renewed interest.
During the last 5 years radioimmunotherapy (RIT), a modality previously developed only for cancer treatment, has been successfully adapted for the treatment of experimental fungal, bacterial, and viral infections.
As our model organism for studying the efficacy, mechanisms, potential toxicity, and radioresistance to RIT, as well as for comparison of RIT with the existing antimicrobial therapies we have chosen the encapsulated yeast Cryptococcus neoformans (CN).
The success of RIT approach in laboratory studies provides encouragement for feasibility of therapeutically targeting microbes with labeled antibodies.
In addition, the creation of “panantibodies” for RIT which would recognize antigens shared by the whole class of pathogens such as fungi, for example, would facilitate the introduction of RIT into the clinic.
American Psychological Association (APA)
Dadachova, Ekaterina& Casadevall, Arturo. 2011. Cryptococcus neoformans as a Model for Radioimmunotherapy of Infections. Interdisciplinary Perspectives on Infectious Diseases،Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-501543
Modern Language Association (MLA)
Dadachova, Ekaterina& Casadevall, Arturo. Cryptococcus neoformans as a Model for Radioimmunotherapy of Infections. Interdisciplinary Perspectives on Infectious Diseases No. 2011 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-501543
American Medical Association (AMA)
Dadachova, Ekaterina& Casadevall, Arturo. Cryptococcus neoformans as a Model for Radioimmunotherapy of Infections. Interdisciplinary Perspectives on Infectious Diseases. 2011. Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-501543
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-501543