Computational Modeling of Tumor Response to Vascular-Targeting Therapies—Part I : Validation
Author
Source
Computational and Mathematical Methods in Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-03-23
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
Mathematical modeling techniques have been widely employed to understand how cancer grows, and, more recently, such approaches have been used to understand how cancer can be controlled.
In this manuscript, a previously validated hybrid cellular automaton model of tumor growth in a vascularized environment is used to study the antitumor activity of several vascular-targeting compounds of known efficacy.
In particular, this model is used to test the antitumor activity of a clinically used angiogenesis inhibitor (both in isolation, and with a cytotoxic chemotherapeutic) and a vascular disrupting agent currently undergoing clinical trial testing.
I demonstrate that the mathematical model can make predictions in agreement with preclinical/clinical data and can also be used to gain more insight into these treatment protocols.
The results presented herein suggest that vascular-targeting agents, as currently administered, cannot lead to cancer eradication, although a highly efficacious agent may lead to long-term cancer control.
American Psychological Association (APA)
Gevertz, Jana L.. 2011. Computational Modeling of Tumor Response to Vascular-Targeting Therapies—Part I : Validation. Computational and Mathematical Methods in Medicine،Vol. 2011, no. 2011, pp.1-17.
https://search.emarefa.net/detail/BIM-501565
Modern Language Association (MLA)
Gevertz, Jana L.. Computational Modeling of Tumor Response to Vascular-Targeting Therapies—Part I : Validation. Computational and Mathematical Methods in Medicine No. 2011 (2011), pp.1-17.
https://search.emarefa.net/detail/BIM-501565
American Medical Association (AMA)
Gevertz, Jana L.. Computational Modeling of Tumor Response to Vascular-Targeting Therapies—Part I : Validation. Computational and Mathematical Methods in Medicine. 2011. Vol. 2011, no. 2011, pp.1-17.
https://search.emarefa.net/detail/BIM-501565
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-501565