Freshwater Clam Extract Ameliorates Triglyceride and Cholesterol Metabolism through the Expression of Genes Involved in Hepatic Lipogenesis and Cholesterol Degradation in Rats
Joint Authors
Oda, Hiroaki
Laurent, Thomas
Tatsuguchi, Iwao
Kobayashi, Satoru
Mochizuki, Satoshi
Chijimatsu, Takeshi
Kataoka, Yutaro
Okuda, Yuji
Umeki, Miki
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-02-12
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The freshwater clam (Corbicula spp.) is a popular edible bivalve and has been used as a folk remedy for liver disease in Asia.
As a Chinese traditional medicine, it is said that freshwater clam ameliorates alcoholic intoxication and cholestasis.
In this study, to estimate the practical benefit of freshwater clam extract (FCE), we compared the effects of FCE and soy protein isolate (SPI) on triglyceride and cholesterol metabolism in rats.
FCE and SPI lowered serum cholesterol, and FCE tended to reduce serum triglycerides.
FCE enhanced fecal sterol excretion and hepatic mRNA levels of CYP7A1 and ABCG5 more substantially than SPI; however, both diets reduced hepatic cholesterol.
Both of the diets similarly suppressed liver lipids improved Δ9-desaturated fatty acid profile, and FCE was associated with a reduction in FAS and SCD1 mRNA levels.
Hepatic transcriptome analysis revealed that inhibition of lipogenesis-related gene expression may contribute to downregulation of hepatic triglycerides by FCE.
FCE would have better potential benefits for preventing metabolic disorders, through greater improvement of metabolism of triglycerides and cholesterol, likely through a mechanism similar to SPI.
American Psychological Association (APA)
Laurent, Thomas& Okuda, Yuji& Chijimatsu, Takeshi& Umeki, Miki& Kobayashi, Satoru& Kataoka, Yutaro…[et al.]. 2013. Freshwater Clam Extract Ameliorates Triglyceride and Cholesterol Metabolism through the Expression of Genes Involved in Hepatic Lipogenesis and Cholesterol Degradation in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-501581
Modern Language Association (MLA)
Laurent, Thomas…[et al.]. Freshwater Clam Extract Ameliorates Triglyceride and Cholesterol Metabolism through the Expression of Genes Involved in Hepatic Lipogenesis and Cholesterol Degradation in Rats. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-501581
American Medical Association (AMA)
Laurent, Thomas& Okuda, Yuji& Chijimatsu, Takeshi& Umeki, Miki& Kobayashi, Satoru& Kataoka, Yutaro…[et al.]. Freshwater Clam Extract Ameliorates Triglyceride and Cholesterol Metabolism through the Expression of Genes Involved in Hepatic Lipogenesis and Cholesterol Degradation in Rats. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-501581
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-501581