Novel Insights into the Genetic Controls of Primitive and Definitive Hematopoiesis from Zebrafish Models
Joint Authors
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-25
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Hematopoiesis is a dynamic process where initiation and maintenance of hematopoietic stem cells, as well as their differentiation into erythroid, myeloid and lymphoid lineages, are tightly regulated by a network of transcription factors.
Understanding the genetic controls of hematopoiesis is crucial as perturbations in hematopoiesis lead to diseases such as anemia, thrombocytopenia, or cancers, including leukemias and lymphomas.
Animal models, particularly conventional and conditional knockout mice, have played major roles in our understanding of the genetic controls of hematopoiesis.
However, knockout mice for most of the hematopoietic transcription factors are embryonic lethal, thus precluding the analysis of their roles during the transition from embryonic to adult hematopoiesis.
Zebrafish are an ideal model organism to determine the function of a gene during embryonic-to-adult transition of hematopoiesis since bloodless zebrafish embryos can develop normally into early larval stage by obtaining oxygen through diffusion.
In this review, we discuss the current status of the ontogeny and regulation of hematopoiesis in zebrafish.
By providing specific examples of zebrafish morphants and mutants, we have highlighted the contributions of the zebrafish model to our overall understanding of the roles of transcription factors in regulation of primitive and definitive hematopoiesis.
American Psychological Association (APA)
Sood, Raman& Liu, Paul. 2012. Novel Insights into the Genetic Controls of Primitive and Definitive Hematopoiesis from Zebrafish Models. Advances in Hematology،Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-501584
Modern Language Association (MLA)
Sood, Raman& Liu, Paul. Novel Insights into the Genetic Controls of Primitive and Definitive Hematopoiesis from Zebrafish Models. Advances in Hematology No. 2012 (2012), pp.1-13.
https://search.emarefa.net/detail/BIM-501584
American Medical Association (AMA)
Sood, Raman& Liu, Paul. Novel Insights into the Genetic Controls of Primitive and Definitive Hematopoiesis from Zebrafish Models. Advances in Hematology. 2012. Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-501584
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-501584