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Cytoskeletal Strains in Modeled Optohydrodynamically Stressed Healthy and Diseased Biological Cells
Joint Authors
Liang, Yu
Kohles, Sean S.
Saha, Asit K.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-05
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Controlled external chemomechanical stimuli have been shown to influence cellular and tissue regeneration/degeneration, especially with regards to distinct disease sequelae or health maintenance.
Recently, a unique three-dimensional stress state was mathematically derived to describe the experimental stresses applied to isolated living cells suspended in an optohydrodynamic trap (optical tweezers combined with microfluidics).
These formulae were previously developed in two and three dimensions from the fundamental equations describing creeping flows past a suspended sphere.
The objective of the current study is to determine the full-field cellular strain response due to the applied three-dimensional stress environment through a multiphysics computational simulation.
In this investigation, the multiscale cytoskeletal structures are modeled as homogeneous, isotropic, and linearly elastic.
The resulting computational biophysics can be directly compared with experimental strain measurements, other modeling interpretations of cellular mechanics including the liquid drop theory, and biokinetic models of biomolecule dynamics.
The described multiphysics computational framework will facilitate more realistic cytoskeletal model interpretations, whose intracellular structures can be distinctly defined, including the cellular membrane substructures, nucleus, and organelles.
American Psychological Association (APA)
Kohles, Sean S.& Liang, Yu& Saha, Asit K.. 2012. Cytoskeletal Strains in Modeled Optohydrodynamically Stressed Healthy and Diseased Biological Cells. Journal of Biophysics،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-501588
Modern Language Association (MLA)
Kohles, Sean S.…[et al.]. Cytoskeletal Strains in Modeled Optohydrodynamically Stressed Healthy and Diseased Biological Cells. Journal of Biophysics No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-501588
American Medical Association (AMA)
Kohles, Sean S.& Liang, Yu& Saha, Asit K.. Cytoskeletal Strains in Modeled Optohydrodynamically Stressed Healthy and Diseased Biological Cells. Journal of Biophysics. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-501588
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-501588