Prognostic and Survival Factors in Myxofibrosarcomas

Abstract EN

Aim.

Our study aimed to determine prognostic factors for survival and recurrence in myxofibrosarcomas based on the experience of a single institution.

Methods.

Patients who had been diagnosed with a myxofibrosarcoma were identified from our database.

Survival and recurrence were evaluated with Kaplan Meier survival curves for univariate and cox regression for multivariate analysis.

Results.

174 patients with a diagnosis of myxofibrosarcoma were identified.

Two patients were excluded due to incomplete information, leaving 172 patients with a mean age of 67 years.

Surgery was undertaken in all but 6 patients.

Five-year survival was better for myxofibrosarcomas when compared to other soft tissue sarcomas (63% versus 57%).

Size, grade of tumour, age, and metastases were all found to be prognostic factors.

Local recurrence occurred in 29 patients (17%) with an overall risk of 15% at 5 years.

Previous inadvertent excision significantly raised this risk to 45%.

Wide surgical margins and depth of tumour, however, had no impact on recurrence.

Conclusion.

Factors previously identified as prognostic did not demonstrate such a relationship in our study, highlighting the unpredictable nature of myxofibrosarcomas.

Future treatment may lie in developing an understanding molecular basis of the tumour and directing therapies accordingly.