Waist-to-Hip Ratio, Cardiovascular Outcomes, and Death in Peritoneal Dialysis Patients
Joint Authors
Su, Winnie S.
Wilkieson, Trevor J.
Gangji, Azim S.
Clase, Catherine M.
Brimble, K. Scott
Margetts, Peter J.
Source
International Journal of Nephrology
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-07-05
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Objectives.
The primary objective of this study was to determine the relationship between waist-to-hip ratio (WHR), cardiovascular (CV) events, and mortality in peritoneal dialysis (PD) patients.
A secondary objective was to investigate the association between abdominal obesity and systemic inflammatory markers.
Methods.
This is a prospective study of 22 prevalent PD patients.
WHR was measured at baseline.
C-reactive protein (CRP), tumour necrosis factor-α (TNF-α), and interleukin-6 (IL-6) were measured.
Main outcomes were first CV event and death from all causes.
Survival analysis was used to examine the relationship between anthropomorphic measures and clinical outcomes.
Results.
Mean follow-up period was 3.1 years.
In Kaplan-Meier analysis, survival was lower in those with higher WHR (P=.002).
In Cox regression, WHR independently predicted mortality and first CV event after adjustment for known ischemic heart disease (hazard ratio [HR] 1.17, confidence interval [CI] 1.05–1.30 for death; HR 1.13, CI 1.01–1.26 for CV event).
WHR correlated with serum TNF-α (r=0.45; P=.05).
Conclusion.
The results of this study suggest WHR may be a risk factor for increased CV events and mortality in PD patients.
Abdominal obesity is also associated with inflammatory markers.
Larger studies are warranted to confirm these findings.
American Psychological Association (APA)
Su, Winnie S.& Clase, Catherine M.& Brimble, K. Scott& Margetts, Peter J.& Wilkieson, Trevor J.& Gangji, Azim S.. 2010. Waist-to-Hip Ratio, Cardiovascular Outcomes, and Death in Peritoneal Dialysis Patients. International Journal of Nephrology،Vol. 2010, no. 2010, pp.1-5.
https://search.emarefa.net/detail/BIM-501632
Modern Language Association (MLA)
Su, Winnie S.…[et al.]. Waist-to-Hip Ratio, Cardiovascular Outcomes, and Death in Peritoneal Dialysis Patients. International Journal of Nephrology No. 2010 (2010), pp.1-5.
https://search.emarefa.net/detail/BIM-501632
American Medical Association (AMA)
Su, Winnie S.& Clase, Catherine M.& Brimble, K. Scott& Margetts, Peter J.& Wilkieson, Trevor J.& Gangji, Azim S.. Waist-to-Hip Ratio, Cardiovascular Outcomes, and Death in Peritoneal Dialysis Patients. International Journal of Nephrology. 2010. Vol. 2010, no. 2010, pp.1-5.
https://search.emarefa.net/detail/BIM-501632
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-501632