Waist-to-Hip Ratio, Cardiovascular Outcomes, and Death in Peritoneal Dialysis Patients

Abstract EN

Objectives.

The primary objective of this study was to determine the relationship between waist-to-hip ratio (WHR), cardiovascular (CV) events, and mortality in peritoneal dialysis (PD) patients.

A secondary objective was to investigate the association between abdominal obesity and systemic inflammatory markers.

Methods.

This is a prospective study of 22 prevalent PD patients.

WHR was measured at baseline.

C-reactive protein (CRP), tumour necrosis factor-α (TNF-α), and interleukin-6 (IL-6) were measured.

Main outcomes were first CV event and death from all causes.

Survival analysis was used to examine the relationship between anthropomorphic measures and clinical outcomes.

Results.

Mean follow-up period was 3.1 years.

In Kaplan-Meier analysis, survival was lower in those with higher WHR (P=.002).

In Cox regression, WHR independently predicted mortality and first CV event after adjustment for known ischemic heart disease (hazard ratio [HR] 1.17, confidence interval [CI] 1.05–1.30 for death; HR 1.13, CI 1.01–1.26 for CV event).

WHR correlated with serum TNF-α (r=0.45; P=.05).

Conclusion.

The results of this study suggest WHR may be a risk factor for increased CV events and mortality in PD patients.

Abdominal obesity is also associated with inflammatory markers.

Larger studies are warranted to confirm these findings.