Collaborating with the Enemy : Function of Macrophages in the Development of Neoplastic Disease
Joint Authors
Eljaszewicz, Andrzej
Helmin-Basa, Anna
Gackowska, Lidia
Zegarski, Wojciech
Wiese, Małgorzata
Jankowski, Michal
Kaszewski, Wojciech
Michalkiewicz, Jacek
Kubiszewska, Izabela
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-17
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Due to the profile of released mediators (such as cytokines, chemokines, growth factors, etc.), neoplastic cells modulate the activity of immune system, directly affecting its components both locally and peripherally.
This is reflected by the limited antineoplastic activity of the immune system (immunosuppressive effect), induction of tolerance to neoplastic antigens, and the promotion of processes associated with the proliferation of neoplastic tissue.
Most of these responses are macrophages dependent, since these cells show proangiogenic properties, attenuate the adaptive response (anergization of naïve T lymphocytes, induction of Treg cell formation, polarization of immune response towards Th2, etc.), and support invasion and metastases formation.
Tumor-associated macrophages (TAMs), a predominant component of leukocytic infiltrate, “cooperate” with the neoplastic tissue, leading to the intensified proliferation and the immune escape of the latter.
This paper characterizes the function of macrophages in the development of neoplastic disease.
American Psychological Association (APA)
Eljaszewicz, Andrzej& Wiese, Małgorzata& Helmin-Basa, Anna& Jankowski, Michal& Gackowska, Lidia& Kubiszewska, Izabela…[et al.]. 2013. Collaborating with the Enemy : Function of Macrophages in the Development of Neoplastic Disease. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-501647
Modern Language Association (MLA)
Eljaszewicz, Andrzej…[et al.]. Collaborating with the Enemy : Function of Macrophages in the Development of Neoplastic Disease. Mediators of Inflammation No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-501647
American Medical Association (AMA)
Eljaszewicz, Andrzej& Wiese, Małgorzata& Helmin-Basa, Anna& Jankowski, Michal& Gackowska, Lidia& Kubiszewska, Izabela…[et al.]. Collaborating with the Enemy : Function of Macrophages in the Development of Neoplastic Disease. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-501647
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-501647