Chimerism-Based Experimental Models for Tolerance Induction in Vascularized Composite Allografts : Cleveland Clinic Research Experience
Joint Authors
Klimczak, Aleksandra
Siemionow, Maria
Source
Clinical and Developmental Immunology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-14
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The preclinical experimental models of vascularized composite allografts (VCAs) have been rapidly developed for the assessment of immunomodulatory protocols for clinical application.
Recently, researchers have focused on immunomodulatory protocols which overcome the immunologic barrier between the allogeneic donor and recipient and may lead to tolerance induction.
In order to test the feasibility of chimerism induction, experimental VCAs have been performed in different models including rodents, large animals, and nonhuman primates.
These models differ in the complexity of transplanted tissue and in their responses to immunomodulatory protocols.
In most applications, VCA contains multiple-tissue components; however, each individual component of CTA possesses unique immunologic characteristics that ultimately contribute to the chimerism induction and successful outcome of the VCA.
Heterogenic character and complexity of tissue components in different VCA models determine the quality and robustness of donor-specific chimerism.
As introduced in experimental studies, variable immunomodulatory options have been studied to achieve tolerance to VCA in rodents and large animal models allowing for widespread application in clinic.
In this paper, based on our own experience, we have analyzed the current knowledge of tolerance-inducing strategies via chimerism induction in VCA experimental models in the context of immunomodulatory protocols and VCA complexity and their relevance and applicability to clinical practice.
American Psychological Association (APA)
Siemionow, Maria& Klimczak, Aleksandra. 2013. Chimerism-Based Experimental Models for Tolerance Induction in Vascularized Composite Allografts : Cleveland Clinic Research Experience. Clinical and Developmental Immunology،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-501651
Modern Language Association (MLA)
Siemionow, Maria& Klimczak, Aleksandra. Chimerism-Based Experimental Models for Tolerance Induction in Vascularized Composite Allografts : Cleveland Clinic Research Experience. Clinical and Developmental Immunology No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-501651
American Medical Association (AMA)
Siemionow, Maria& Klimczak, Aleksandra. Chimerism-Based Experimental Models for Tolerance Induction in Vascularized Composite Allografts : Cleveland Clinic Research Experience. Clinical and Developmental Immunology. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-501651
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-501651