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Vaxjo : A Web-Based Vaccine Adjuvant Database and Its Application for Analysis of Vaccine Adjuvants and Their Uses in Vaccine Development
Joint Authors
Sayers, Samantha
Xiang, Zuoshuang
He, Yongqun Oliver
Ulysse, Guerlain
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-13
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Vaccine adjuvants are compounds that enhance host immune responses to co-administered antigens in vaccines.
Vaxjo is a web-based central database and analysis system that curates, stores, and analyzes vaccine adjuvants and their usages in vaccine development.
Basic information of a vaccine adjuvant stored in Vaxjo includes adjuvant name, components, structure, appearance, storage, preparation, function, safety, and vaccines that use this adjuvant.
Reliable references are curated and cited.
Bioinformatics scripts are developed and used to link vaccine adjuvants to different adjuvanted vaccines stored in the general VIOLIN vaccine database.
Presently, 103 vaccine adjuvants have been curated in Vaxjo.
Among these adjuvants, 98 have been used in 384 vaccines stored in VIOLIN against over 81 pathogens, cancers, or allergies.
All these vaccine adjuvants are categorized and analyzed based on adjuvant types, pathogens used, and vaccine types.
As a use case study of vaccine adjuvants in infectious disease vaccines, the adjuvants used in Brucella vaccines are specifically analyzed.
A user-friendly web query and visualization interface is developed for interactive vaccine adjuvant search.
To support data exchange, the information of vaccine adjuvants is stored in the Vaccine Ontology (VO) in the Web Ontology Language (OWL) format.
American Psychological Association (APA)
Sayers, Samantha& Ulysse, Guerlain& Xiang, Zuoshuang& He, Yongqun Oliver. 2012. Vaxjo : A Web-Based Vaccine Adjuvant Database and Its Application for Analysis of Vaccine Adjuvants and Their Uses in Vaccine Development. Journal of Biomedicine and Biotechnology،Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-501659
Modern Language Association (MLA)
Sayers, Samantha…[et al.]. Vaxjo : A Web-Based Vaccine Adjuvant Database and Its Application for Analysis of Vaccine Adjuvants and Their Uses in Vaccine Development. Journal of Biomedicine and Biotechnology No. 2012 (2012), pp.1-13.
https://search.emarefa.net/detail/BIM-501659
American Medical Association (AMA)
Sayers, Samantha& Ulysse, Guerlain& Xiang, Zuoshuang& He, Yongqun Oliver. Vaxjo : A Web-Based Vaccine Adjuvant Database and Its Application for Analysis of Vaccine Adjuvants and Their Uses in Vaccine Development. Journal of Biomedicine and Biotechnology. 2012. Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-501659
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-501659