Mechanisms and Implications of Age-Related Changes in the Liver : Nonalcoholic Fatty Liver Disease in the Elderly

Joint Authors

Chitturi, Shivakumar
Gan, Lay
Farrell, Geoffrey C.

Source

Current Gerontology and Geriatrics Research

Issue

Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-12, 12 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2011-09-12

Country of Publication

Egypt

No. of Pages

12

Main Subjects

Diseases

Abstract EN

Nonalcoholic fatty liver disease (NAFLD) is hepatic steatosis associated with metabolic abnormalities such as overweight/central obesity, insulin resistance, type 2 diabetes (T2D), and dyslipidemia.

NAFLD is becoming the most common liver disease in contemporary society, with the highest prevalence in those over 60 years.

NAFLD pathology ranges from simple steatosis to a necroinflammatory fibrosing disorder called steatohepatitis (SH), the latter associated with high risk of developing cirrhosis, often occuring in the seventh to ninth decades of life.

While the main health implications of NAFLD are increased risk of developing T2D, cardiovascular diseases, and common cancers, there is substantantially increased standardized mortality, and deaths from decompensated cirrhosis and hepatocellular carcinoma (HCC).

Little is known about the interactive effects of ageing and NAFLD, with most studies focusing on the younger population.

This paper summarises the epidemiology, pathogenesis, and clinical course of NAFLD, with particular attention to persons over age 60 years.

An approach to the management of NASH and its complications in the elderly, will also be presented here.

American Psychological Association (APA)

Gan, Lay& Chitturi, Shivakumar& Farrell, Geoffrey C.. 2011. Mechanisms and Implications of Age-Related Changes in the Liver : Nonalcoholic Fatty Liver Disease in the Elderly. Current Gerontology and Geriatrics Research،Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-501665

Modern Language Association (MLA)

Gan, Lay…[et al.]. Mechanisms and Implications of Age-Related Changes in the Liver : Nonalcoholic Fatty Liver Disease in the Elderly. Current Gerontology and Geriatrics Research No. 2011 (2011), pp.1-12.
https://search.emarefa.net/detail/BIM-501665

American Medical Association (AMA)

Gan, Lay& Chitturi, Shivakumar& Farrell, Geoffrey C.. Mechanisms and Implications of Age-Related Changes in the Liver : Nonalcoholic Fatty Liver Disease in the Elderly. Current Gerontology and Geriatrics Research. 2011. Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-501665

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-501665