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Treatment Comparison in Rheumatoid Arthritis : Head-to-Head Trials and Innovative Study Designs
Joint Authors
Caporali, Roberto
Biggioggero, Martina
Favalli, Ennio Giulio
Bugatti, Serena
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-16
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
Over the last decades, the increasing knowledge in the area of rheumatoid arthritis has progressively expanded the arsenal of available drugs, especially with the introduction of novel targeted therapies such as biological disease modifying antirheumatic drugs (DMARDs).
In this situation, rheumatologists are offered a wide range of treatment options, but on the other side the need for comparisons between available drugs becomes more and more crucial in order to better define the strategies for the choice and the optimal sequencing.
Indirect comparisons or meta-analyses of data coming from different randomised controlled trials (RCTs) are not immune to conceptual and technical challenges and often provide inconsistent results.
In this review we examine some of the possible evolutions of traditional RCTs, such as the inclusion of active comparators, aimed at individualising treatments in real-life conditions.
Although head-to-head RCTs may be considered the best tool to directly compare the efficacy and safety of two different DMARDs, surprisingly only 20 studies with such design have been published in the last 25 years.
Given the recent advent of the first RCTs truly comparing biological DMARDs, we also review the state of the art of head-to-head trials in RA.
American Psychological Association (APA)
Favalli, Ennio Giulio& Bugatti, Serena& Biggioggero, Martina& Caporali, Roberto. 2014. Treatment Comparison in Rheumatoid Arthritis : Head-to-Head Trials and Innovative Study Designs. BioMed Research International،Vol. 2014, no. 2014, pp.1-17.
https://search.emarefa.net/detail/BIM-501671
Modern Language Association (MLA)
Favalli, Ennio Giulio…[et al.]. Treatment Comparison in Rheumatoid Arthritis : Head-to-Head Trials and Innovative Study Designs. BioMed Research International No. 2014 (2014), pp.1-17.
https://search.emarefa.net/detail/BIM-501671
American Medical Association (AMA)
Favalli, Ennio Giulio& Bugatti, Serena& Biggioggero, Martina& Caporali, Roberto. Treatment Comparison in Rheumatoid Arthritis : Head-to-Head Trials and Innovative Study Designs. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-17.
https://search.emarefa.net/detail/BIM-501671
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-501671