Simvastatin Attenuates Contrast-Induced Nephropathy through Modulation of Oxidative Stress, Proinflammatory Myeloperoxidase, and Nitric Oxide
Joint Authors
al-Otaibi, Ketab E.
al-Asmari, Abdulrahman K.
Tariq, Mohammad
al-Elaiwi, Abdulrahman M.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-10
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Contrast media- (CM-) induced nephropathy is a serious complication of radiodiagnostic procedures.
Available data suggests that the development of prophylaxis strategies is limited by poor understanding of pathophysiology of CM-induced nephropathy.
Present study was designed to determine the role of oxidative stress, myeloperoxidase, and nitric oxide in the pathogenesis of iohexol model of nephropathy and its modification with simvastatin (SSTN).
Adult Sprague Dawley rats were divided into seven groups.
After 24 h of water deprivation, all the rats except in control and SSTN-only groups were injected (10 ml/kg) with 25% glycerol.
After 30 min, SSTN (15, 30, and 60 mg/kg) was administered orally, daily for 4 days.
Twenty-four hours after the glycerol injection, iohexol was infused (8 ml/kg) through femoral vein over a period of 2 min.
All the animals were sacrificed on day 5 and blood and kidneys were collected for biochemical and histological studies.
The results showed that SSTN dose dependently attenuated CM-induced rise of creatinine, urea, and structural abnormalities suggesting its nephroprotective effect.
A significant increase in oxidative stress (increased lipid hydroperoxides and reduced glutathione levels) and myeloperoxidase (MPO) and decreased nitric oxide in CM group were reversed by SSTN.
These findings support the use of SSTN to combat CM-induced nephrotoxicity.
American Psychological Association (APA)
al-Otaibi, Ketab E.& al-Elaiwi, Abdulrahman M.& Tariq, Mohammad& al-Asmari, Abdulrahman K.. 2012. Simvastatin Attenuates Contrast-Induced Nephropathy through Modulation of Oxidative Stress, Proinflammatory Myeloperoxidase, and Nitric Oxide. Oxidative Medicine and Cellular Longevity،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-501691
Modern Language Association (MLA)
al-Otaibi, Ketab E.…[et al.]. Simvastatin Attenuates Contrast-Induced Nephropathy through Modulation of Oxidative Stress, Proinflammatory Myeloperoxidase, and Nitric Oxide. Oxidative Medicine and Cellular Longevity No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-501691
American Medical Association (AMA)
al-Otaibi, Ketab E.& al-Elaiwi, Abdulrahman M.& Tariq, Mohammad& al-Asmari, Abdulrahman K.. Simvastatin Attenuates Contrast-Induced Nephropathy through Modulation of Oxidative Stress, Proinflammatory Myeloperoxidase, and Nitric Oxide. Oxidative Medicine and Cellular Longevity. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-501691
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-501691