Growth Inhibition by Bupivacaine Is Associated with Inactivation of Ribosomal Protein S6 Kinase 1
Joint Authors
Bashir, Basharat
Showkat, Mehvish
Bashir, Asma
Beigh, Mushtaq Ahmad
Hussain, Mahboob ul
Andrabi, Khurshid Iqbal
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-29
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Bupivacaine is an amide type long acting local anesthetic used for epidural anesthesia and nerve blockade in patients.
Use of bupivacaine is associated with severe cytotoxicity and apoptosis along with inhibition of cell growth and proliferation.
Although inhibition of Erk, Akt, and AMPK seemingly appears to mediate some of the bupivacaine effects, potential downstream targets that mediate its effect remain unknown.
S6 kinase 1 is a common downstream effector of several growth regulatory pathways involved in cell growth and proliferation known to be affected by bupivacaine.
We have accordingly attempted to relate the growth inhibitory effects of bupivacaine with the status of S6K1 activity and we present evidence that decrease in cell growth and proliferation by bupivacaine is mediated through inactivation of S6 kinase 1 in a concentration and time dependent manner.
We also show that ectopic expression of constitutively active S6 kinase 1 imparts substantial protection from bupivacaine induced cytotoxicity.
Inactivation of S6K1 though associated with loss of putative mTOR mediated phosphorylation did not correspond with loss of similar phosphorylations in 4EBP1 indicating that S6K1 inhibition was not mediated through inactivation of mTORC1 signaling pathway or its down regulation.
American Psychological Association (APA)
Beigh, Mushtaq Ahmad& Showkat, Mehvish& Bashir, Basharat& Bashir, Asma& Hussain, Mahboob ul& Andrabi, Khurshid Iqbal. 2014. Growth Inhibition by Bupivacaine Is Associated with Inactivation of Ribosomal Protein S6 Kinase 1. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-501699
Modern Language Association (MLA)
Beigh, Mushtaq Ahmad…[et al.]. Growth Inhibition by Bupivacaine Is Associated with Inactivation of Ribosomal Protein S6 Kinase 1. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-501699
American Medical Association (AMA)
Beigh, Mushtaq Ahmad& Showkat, Mehvish& Bashir, Basharat& Bashir, Asma& Hussain, Mahboob ul& Andrabi, Khurshid Iqbal. Growth Inhibition by Bupivacaine Is Associated with Inactivation of Ribosomal Protein S6 Kinase 1. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-501699
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-501699