Hybrid Anion Exchange Hollow Fiber Membrane for Delivery of Ionic Drugs
Joint Authors
Wang, Na
Xu, Tongwen
Cui, Mengbing
Cheng, Yiyun
Wu, Cuiming
Source
International Journal of Chemical Engineering
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-22
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Engineering Sciences and Information Technology
Abstract EN
Hybrid anion exchange hollow fiber membranes (HAEHFMs) based on bromomethylated poly(2,6-dimethyl-1,4-phenylene oxide) (BPPO) are proposed as potential drug carriers for four anionic model drugs, including the sodium salts of benzoate (NaBS), salicylate (NaSA), meta-amino salicylate (NaMAS), and loxoprofen (NaLS).
The results of the static loading and release experiments suggest that electrostatic interaction, hydrogen bonding, and hydrophobic interaction are the main interaction patterns between the membrane and the drugs.
And they are directly influenced by the external phase conditions and the drug physicochemical characteristics, such as structure, molecular weight, dissociation (pKa), and hydrogen bonding capability.
Among the four different drugs, NaSA and NaMAS appear to be the most suitable for controlled release by the HAEHFM due to their excellent adsorption/release behaviors.
American Psychological Association (APA)
Wang, Na& Cui, Mengbing& Wu, Cuiming& Cheng, Yiyun& Xu, Tongwen. 2012. Hybrid Anion Exchange Hollow Fiber Membrane for Delivery of Ionic Drugs. International Journal of Chemical Engineering،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-501735
Modern Language Association (MLA)
Wang, Na…[et al.]. Hybrid Anion Exchange Hollow Fiber Membrane for Delivery of Ionic Drugs. International Journal of Chemical Engineering No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-501735
American Medical Association (AMA)
Wang, Na& Cui, Mengbing& Wu, Cuiming& Cheng, Yiyun& Xu, Tongwen. Hybrid Anion Exchange Hollow Fiber Membrane for Delivery of Ionic Drugs. International Journal of Chemical Engineering. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-501735
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-501735