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Proposing Low-Similarity Peptide Vaccines against Mycobacterium tuberculosis
Joint Authors
Kanduc, Darja
Lucchese, Guglielmo
Stufano, Angela
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-06-03
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Using the currently available proteome databases and based on the concept that a rare sequence is a potential epitope, epitopic sequences derived from Mycobacterium tuberculosis were examined for similarity score to the proteins of the host in which the epitopes were defined.
We found that: (i) most of the bacterial linear determinants had peptide fragment(s) that were rarely found in the host proteins and (ii) the relationship between low similarity and epitope definition appears potentially applicable to T-cell determinants.
The data confirmed the hypothesis that low-sequence similarity shapes or determines the epitope definition at the molecular level and provides a potential tool for designing new approaches to prevent, diagnose, and treat tuberculosis and other infectious diseases.
American Psychological Association (APA)
Lucchese, Guglielmo& Stufano, Angela& Kanduc, Darja. 2010. Proposing Low-Similarity Peptide Vaccines against Mycobacterium tuberculosis. Journal of Biomedicine and Biotechnology،Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-501741
Modern Language Association (MLA)
Lucchese, Guglielmo…[et al.]. Proposing Low-Similarity Peptide Vaccines against Mycobacterium tuberculosis. Journal of Biomedicine and Biotechnology No. 2010 (2010), pp.1-8.
https://search.emarefa.net/detail/BIM-501741
American Medical Association (AMA)
Lucchese, Guglielmo& Stufano, Angela& Kanduc, Darja. Proposing Low-Similarity Peptide Vaccines against Mycobacterium tuberculosis. Journal of Biomedicine and Biotechnology. 2010. Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-501741
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-501741