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Transplantation of Nonexpanded Adipose Stromal Vascular Fraction and Platelet-Rich Plasma for Articular Cartilage Injury Treatment in Mice Model
Joint Authors
Van Pham, Phuc
Tan Khuat, Lam
Quoc Ngo, Dat
Hong-Thien Bui, Khanh
Kim Phan, Ngoc
Source
Journal of Medical Engineering
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-01-16
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Stromal vascular fraction (SVF) combined with platelet-rich plasma (PRP) is commonly used in preclinical and clinical osteoarthritis as well as articular cartilage injury treatment.
However, this therapy has not carefully evaluated the safety and the efficacy.
This research aims to assess the safety and the efficacy of SVF combined with PRP transplantation.
Ten samples of SVFs and PRPs from donors were used in this research.
About safety, we evaluate the expression of some genes related to tumor formation such as Oct-4, Nanog, SSEA3, and SSEA4 by RT-PCR, flow cytometry, and tumor formation when injected in NOD/SCID mice.
About efficacy, SVF was injected with PRP into murine joint that caused joint failure.
The results showed that SVFs are negative with Oct-4, Nanog, SSEA-3, and SSEA-4, as well as they cannot cause tumors in mice.
SVFs combined with PRP can improve the joint regeneration in mice.
These results proved that SVFs combined with PRP transplantation is a promising therapy for articular cartilage injury treatment.
American Psychological Association (APA)
Van Pham, Phuc& Hong-Thien Bui, Khanh& Quoc Ngo, Dat& Tan Khuat, Lam& Kim Phan, Ngoc. 2013. Transplantation of Nonexpanded Adipose Stromal Vascular Fraction and Platelet-Rich Plasma for Articular Cartilage Injury Treatment in Mice Model. Journal of Medical Engineering،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-501743
Modern Language Association (MLA)
Van Pham, Phuc…[et al.]. Transplantation of Nonexpanded Adipose Stromal Vascular Fraction and Platelet-Rich Plasma for Articular Cartilage Injury Treatment in Mice Model. Journal of Medical Engineering No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-501743
American Medical Association (AMA)
Van Pham, Phuc& Hong-Thien Bui, Khanh& Quoc Ngo, Dat& Tan Khuat, Lam& Kim Phan, Ngoc. Transplantation of Nonexpanded Adipose Stromal Vascular Fraction and Platelet-Rich Plasma for Articular Cartilage Injury Treatment in Mice Model. Journal of Medical Engineering. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-501743
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-501743