Quantification of Lansoprazole in Oral Suspension by Ultra-High-Performance Liquid Chromatography Hybrid Ion-Trap Time-of-Flight Mass Spectrometry
Joint Authors
Connor, Justin D.
Lugo, Ralph A.
Brown, Stacy D.
Smallwood, Nicholas C.
Source
International Journal of Analytical Chemistry
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-22
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
An LC-MS/MS method was developed and validated to be used as a stability indicating assay for the study of a 3 mg/mL lansoprazole oral suspension.
The method utilizes a UPLC (ultra-performance liquid chromatography) column and unique mass spectrometric detection (ion-trap time-of-flight (IT-TOF)) to achieve a sensitive (LOD 2 ng/mL), accurate, and reproducible quantification of lansoprazole.
This method reports an intraday and interday coefficient of variation of 2.98 ± 2.17% (n=5 for each concentration for each day) and 3.07 ± 0.89% (n=20 for each concentration), respectively.
Calibration curves (5–25 μg/mL) were found to be linear with an R2 value ranging from 0.9972 to 0.9991 on 4 different days.
Accuracy of the assay, expressed as % error, ranged from 0.30 to 5.22%.
This method is useful for monitoring the stability of lansoprazole in oral suspension.
American Psychological Association (APA)
Brown, Stacy D.& Connor, Justin D.& Smallwood, Nicholas C.& Lugo, Ralph A.. 2011. Quantification of Lansoprazole in Oral Suspension by Ultra-High-Performance Liquid Chromatography Hybrid Ion-Trap Time-of-Flight Mass Spectrometry. International Journal of Analytical Chemistry،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-501745
Modern Language Association (MLA)
Brown, Stacy D.…[et al.]. Quantification of Lansoprazole in Oral Suspension by Ultra-High-Performance Liquid Chromatography Hybrid Ion-Trap Time-of-Flight Mass Spectrometry. International Journal of Analytical Chemistry No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-501745
American Medical Association (AMA)
Brown, Stacy D.& Connor, Justin D.& Smallwood, Nicholas C.& Lugo, Ralph A.. Quantification of Lansoprazole in Oral Suspension by Ultra-High-Performance Liquid Chromatography Hybrid Ion-Trap Time-of-Flight Mass Spectrometry. International Journal of Analytical Chemistry. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-501745
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-501745