Nitric Oxide in Asthma Physiopathology
Joint Authors
Prado, Carla M.
Tibério, Iolanda F. L. C.
Martins, Milton Arruda
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-04-19
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Asthma is a chronic inflammatory airway disease characterized by allergen-induced airway hyperresponsiveness, airway inflammation, and remodeling.
Nitric oxide (NO) derived from constitutive and inducible enzymes affects many aspects of asthma physiopathology.
Animal in vivo studies have indicated that inhibition of iNOS may play a central role in the modulation of these features, particularly extracellular matrix remodeling.
Additionally, increases in iNOS-derived NO, observed in asthmatic patients, may lead to an increase in peroxynitrite and an imbalance of oxidant and antioxidant pathways.
In addition, endogenous nitric oxide produced by constitutive enzymes may protect against the remodeling of the lung.
Therefore, nitric oxide donors and/or iNOS inhibitors may have therapeutic potential in asthma treatment and can also be used with corticosteroids to counteract airway remodeling.
This paper focuses on the pathophysiological role of nitric oxide, mainly derived from inducible isoforms, in the various pathologic mechanisms of allergic asthma and the importance of nitric oxide and/or arginase inhibitors in asthma treatment.
American Psychological Association (APA)
Prado, Carla M.& Martins, Milton Arruda& Tibério, Iolanda F. L. C.. 2011. Nitric Oxide in Asthma Physiopathology. ISRN Allergy،Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-501761
Modern Language Association (MLA)
Prado, Carla M.…[et al.]. Nitric Oxide in Asthma Physiopathology. ISRN Allergy No. 2011 (2011), pp.1-13.
https://search.emarefa.net/detail/BIM-501761
American Medical Association (AMA)
Prado, Carla M.& Martins, Milton Arruda& Tibério, Iolanda F. L. C.. Nitric Oxide in Asthma Physiopathology. ISRN Allergy. 2011. Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-501761
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-501761