The Role of the Selective Adaptor p62 and Ubiquitin-Like Proteins in Autophagy
Joint Authors
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-12
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The ubiquitin-proteasome system and autophagy were long viewed as independent, parallel degradation systems with no point of intersection.
By now we know that these degradation pathways share certain substrates and regulatory molecules and show coordinated and compensatory function.
Two ubiquitin-like protein conjugation pathways were discovered that are required for autophagosome biogenesis: the Atg12-Atg5-Atg16 and Atg8 systems.
Autophagy has been considered to be essentially a nonselective process, but it turned out to be at least partially selective.
Selective substrates of autophagy include damaged mitochondria, intracellular pathogens, and even a subset of cytosolic proteins with the help of ubiquitin-binding autophagic adaptors, such as p62/SQSTM1, NBR1, NDP52, and Optineurin.
These proteins selectively recognize autophagic cargo and mediate its engulfment into autophagosomes by binding to the small ubiquitin-like modifiers that belong to the Atg8/LC3 family.
American Psychological Association (APA)
Lippai, Mónika& Lőw, Péter. 2014. The Role of the Selective Adaptor p62 and Ubiquitin-Like Proteins in Autophagy. BioMed Research International،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-501775
Modern Language Association (MLA)
Lippai, Mónika& Lőw, Péter. The Role of the Selective Adaptor p62 and Ubiquitin-Like Proteins in Autophagy. BioMed Research International No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-501775
American Medical Association (AMA)
Lippai, Mónika& Lőw, Péter. The Role of the Selective Adaptor p62 and Ubiquitin-Like Proteins in Autophagy. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-501775
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-501775