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Comparative Genomics of Cryptosporidium
Joint Authors
Schwartz, David C.
Alves, João M.
Mazurie, Aurélien J.
Buck, Gregory A.
Ozaki, Luiz S.
Zhou, Shiguo
Source
International Journal of Genomics
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-05-02
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Until recently, the apicomplexan parasites, Cryptosporidium hominis and C.
parvum, were considered the same species.
However, the two parasites, now considered distinct species, exhibit significant differences in host range, infectivity, and pathogenicity, and their sequenced genomes exhibit only 95–97% identity.
The availability of the complete genome sequences of these organisms provides the potential to identify the genetic variations that are responsible for the phenotypic differences between the two parasites.
We compared the genome organization and structure, gene composition, the metabolic and other pathways, and the local sequence identity between the genes of these two Cryptosporidium species.
Our observations show that the phenotypic differences between C.
hominis and C.
parvum are not due to gross genome rearrangements, structural alterations, gene deletions or insertions, metabolic capabilities, or other obvious genomic alterations.
Rather, the results indicate that these genomes exhibit a remarkable structural and compositional conservation and suggest that the phenotypic differences observed are due to subtle variations in the sequences of proteins that act at the interface between the parasite and its host.
American Psychological Association (APA)
Mazurie, Aurélien J.& Alves, João M.& Ozaki, Luiz S.& Zhou, Shiguo& Schwartz, David C.& Buck, Gregory A.. 2013. Comparative Genomics of Cryptosporidium. International Journal of Genomics،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-501783
Modern Language Association (MLA)
Mazurie, Aurélien J.…[et al.]. Comparative Genomics of Cryptosporidium. International Journal of Genomics No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-501783
American Medical Association (AMA)
Mazurie, Aurélien J.& Alves, João M.& Ozaki, Luiz S.& Zhou, Shiguo& Schwartz, David C.& Buck, Gregory A.. Comparative Genomics of Cryptosporidium. International Journal of Genomics. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-501783
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-501783