Oral Administration of Alkylglycerols Differentially Modulates High-Fat Diet-Induced Obesity and Insulin Resistance in Mice
Joint Authors
Sun, Shuna
Cai, Wei
Zhang, Mingshun
Tang, Ning
Qian, Linxi
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-20
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Alkylglycerols (AKGs) from shark liver oil (SLO) were demonstrated to have strong potency to stimulate immune response.
However, no study has been conducted on the effects of AKGs on diet-induced obesity and metabolic inflammatory disorder.
The purpose of the present study was to investigate the effect of two AKGs isoforms on obesity and insulin resistance in mice fed high-fat (HF) diet.
Forty-eight C57BL/6 mice were divided into normal, HF, HF+20 mg/kg selachyl alcohol (SA), HF+200 mg/kg SA, HF+20 mg/kg batyl alcohol (BA), and HF+200 mg/kg BA groups.
Body weight, fasting glucose, lipids, insulin and leptin levels, serum IL-1β, and TNF-α levels were compared among different groups.
Our results showed that high-dose SA decreased body weight, serum triglyceride, cholesterol, fasting glucose level, insulin level, and serum leptin level of the HF fed mice, while high-dose BA increased fasting insulin level of the HF fed mice.
Pretreatment of primary adipocytes with 10 μM SA or BA differentially modulates LPS-mediated MAPK and NF-κB signaling.
Our study demonstrated that oral administration of AKGs has differential effects on HF-induced obesity and metabolic inflammatory disorder in mice.
American Psychological Association (APA)
Zhang, Mingshun& Sun, Shuna& Tang, Ning& Cai, Wei& Qian, Linxi. 2013. Oral Administration of Alkylglycerols Differentially Modulates High-Fat Diet-Induced Obesity and Insulin Resistance in Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-501800
Modern Language Association (MLA)
Zhang, Mingshun…[et al.]. Oral Administration of Alkylglycerols Differentially Modulates High-Fat Diet-Induced Obesity and Insulin Resistance in Mice. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-501800
American Medical Association (AMA)
Zhang, Mingshun& Sun, Shuna& Tang, Ning& Cai, Wei& Qian, Linxi. Oral Administration of Alkylglycerols Differentially Modulates High-Fat Diet-Induced Obesity and Insulin Resistance in Mice. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-501800
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-501800