Caffeine's Vascular Mechanisms of Action
Joint Authors
Cabrera, Mariana
Prieto, Angélica
Echeverri, Darío
Galán, Angélica
Montes, Félix R.
Source
International Journal of Vascular Medicine
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-08-25
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Caffeine is the most widely consumed stimulating substance in the world.
It is found in coffee, tea, soft drinks, chocolate, and many medications.
Caffeine is a xanthine with various effects and mechanisms of action in vascular tissue.
In endothelial cells, it increases intracellular calcium stimulating the production of nitric oxide through the expression of the endothelial nitric oxide synthase enzyme.
Nitric oxide is diffused to the vascular smooth muscle cell to produce vasodilation.
In vascular smooth muscle cells its effect is predominantly a competitive inhibition of phosphodiesterase, producing an accumulation of cAMP and vasodilation.
In addition, it blocks the adenosine receptors present in the vascular tissue to produce vasoconstriction.
In this paper the main mechanisms of action of caffeine on the vascular tissue are described, in which it is shown that caffeine has some cardiovascular properties and effects which could be considered beneficial.
American Psychological Association (APA)
Echeverri, Darío& Montes, Félix R.& Cabrera, Mariana& Galán, Angélica& Prieto, Angélica. 2010. Caffeine's Vascular Mechanisms of Action. International Journal of Vascular Medicine،Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-501803
Modern Language Association (MLA)
Echeverri, Darío…[et al.]. Caffeine's Vascular Mechanisms of Action. International Journal of Vascular Medicine No. 2010 (2010), pp.1-10.
https://search.emarefa.net/detail/BIM-501803
American Medical Association (AMA)
Echeverri, Darío& Montes, Félix R.& Cabrera, Mariana& Galán, Angélica& Prieto, Angélica. Caffeine's Vascular Mechanisms of Action. International Journal of Vascular Medicine. 2010. Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-501803
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-501803