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CA19-9 as a Potential Target for Radiolabeled Antibody-Based Positron Emission Tomography of Pancreas Cancer
Joint Authors
McCabe, Katelyn E.
Girgis, Mark D.
Kenanova, Vania
Olafsen, Tove
Tomlinson, James S.
Wu, Anna M.
Source
International Journal of Molecular Imaging
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-06
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Introduction.
Sensitive and specific imaging of pancreas cancer are necessary for accurate diagnosis, staging, and treatment.
The vast majority of pancreas cancers express the carbohydrate tumor antigen CA19-9.
The goal of this study was to determine the potential to target CA19-9 with a radiolabeled anti-CA19-9 antibody for imaging pancreas cancer.
Methods.
CA19-9 was quantified using flow cytometry on human pancreas cancer cell lines.
An intact murine anti-CA19-9 monoclonal antibody was labeled with a positron emitting radionuclide (Iodine-124) and injected into mice harboring antigen positive and negative xenografts.
MicroPET/CT were performed at successive time intervals (72 hours, 96 hours, 120 hours) after injection.
Radioactivity was measured in blood and tumor to provide objective confirmation of the images.
Results.
Antigen expression by flow cytometry revealed approximately 1.3×106 CA19-9 antigens for the positive cell line and no expression in the negative cell line.
Pancreas xenograft imaging with Iodine-124-labeled anti-CA19-9 mAb demonstrated an average tumor to blood ratio of 5 and positive to negative tumor ratio of 20.
Conclusion.
We show in vivo targeting of our antigen positive xenograft with a radiolabeled anti-CA19-9 antibody.
These data demonstrate the potential to achieve anti-CA19-9 antibody based positron emission tomography of pancreas cancer.
American Psychological Association (APA)
Girgis, Mark D.& Olafsen, Tove& Kenanova, Vania& McCabe, Katelyn E.& Wu, Anna M.& Tomlinson, James S.. 2011. CA19-9 as a Potential Target for Radiolabeled Antibody-Based Positron Emission Tomography of Pancreas Cancer. International Journal of Molecular Imaging،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-501844
Modern Language Association (MLA)
Girgis, Mark D.…[et al.]. CA19-9 as a Potential Target for Radiolabeled Antibody-Based Positron Emission Tomography of Pancreas Cancer. International Journal of Molecular Imaging No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-501844
American Medical Association (AMA)
Girgis, Mark D.& Olafsen, Tove& Kenanova, Vania& McCabe, Katelyn E.& Wu, Anna M.& Tomlinson, James S.. CA19-9 as a Potential Target for Radiolabeled Antibody-Based Positron Emission Tomography of Pancreas Cancer. International Journal of Molecular Imaging. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-501844
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-501844