Synthesis of New Imidazolidine and Tetrahydropyrimidine Derivatives
Joint Authors
Aryan, Reza
Keshtegar, Zahra
Beyzaei, Hamid
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-14
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Synthesis of new imidazolidine and tetrahydropyrimidine derivatives 3a, b and 4a–c as cyclic 1,3-diamines under two reaction conditions (A and B) is described.
Under reaction conditions-A, a suspension of (E)-2-cyano-2-(oxazolidin-2-ylidene)ethanethioamide 1 (1 eq.) and diaminoalkanes 2a–e (2 eq.) in absolute ethanol is heated under reflux for 16–22 h to afford 3a, b and 4a–c.
Alternatively, under reaction conditions-B, a solution of thioamide 1 (1 eq.) in diaminoalkanes 2a–e (3 eq.) is stirred under solvent-free conditions at room temperature for 3 days to give desired products.
Reaction conditions-A for having higher yields, shorter reaction times, and required less diamines is more effective than reaction conditions-B.
Oxazolidine ring opening is observed by reacting compound 1 with all of the diamines 2a–e, but the thioamide group only reacts with nonbulky diamines 2a, b.
The chemical structures of novel compounds were confirmed by 1H NMR, 13C NMR, elemental analysis, and FT-IR spectrometry.
American Psychological Association (APA)
Beyzaei, Hamid& Aryan, Reza& Keshtegar, Zahra. 2014. Synthesis of New Imidazolidine and Tetrahydropyrimidine Derivatives. Advances in Chemistry،Vol. 2014, no. 2014, pp.1-4.
https://search.emarefa.net/detail/BIM-501859
Modern Language Association (MLA)
Beyzaei, Hamid…[et al.]. Synthesis of New Imidazolidine and Tetrahydropyrimidine Derivatives. Advances in Chemistry No. 2014 (2014), pp.1-4.
https://search.emarefa.net/detail/BIM-501859
American Medical Association (AMA)
Beyzaei, Hamid& Aryan, Reza& Keshtegar, Zahra. Synthesis of New Imidazolidine and Tetrahydropyrimidine Derivatives. Advances in Chemistry. 2014. Vol. 2014, no. 2014, pp.1-4.
https://search.emarefa.net/detail/BIM-501859
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-501859