New Insights in the Mobilization of Hematopoietic Stem Cells in Lymphoma and Multiple Myeloma Patients
Joint Authors
Tsirigotis, Panagiotis
Boutsikas, Georgios
Tsirkinidis, Pantelis
Vassilakopoulos, Theodoros P.
Angelopoulou, Maria K.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-14
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Following chemotherapy and/or the administration of growth factors, such as granulocyte-colony stimulated factor (G-CSF), hematopoietic stem cells (HSC) mobilize from bone marrow to peripheral blood.
This review aims to systematically present the structure of the HSC “niche” and elucidate the mechanisms of their mobilization.
However, this field is constantly evolving and new pathways and molecules have been shown to contribute to the mobilization process.
Understanding the importance and the possible primary pathophysiologic role of each pathway is rather difficult, since they share various overlapping components.
The primary initiating event for the mobilization of HSC is chemotherapy-induced endogenous G-CSF production or exogenous G-CSF administration.
G-CSF induces proliferation and expansion of the myelomonocytic series, which leads to proteolytic enzyme activation.
These enzymes result in disruption of various receptor-ligand bonds, which leads to the disanchorage of HSC from the bone marrow stroma.
In everyday clinical practice, CXC chemokine receptor-4 (CXCR4) antagonists are now being used as mobilization agents in order to improve HSC collection.
Furthermore, based on the proposed mechanisms of HSC mobilization, novel mobilizing agents have been developed and are currently evaluated in preclinical and clinical studies.
American Psychological Association (APA)
Angelopoulou, Maria K.& Tsirkinidis, Pantelis& Boutsikas, Georgios& Vassilakopoulos, Theodoros P.& Tsirigotis, Panagiotis. 2014. New Insights in the Mobilization of Hematopoietic Stem Cells in Lymphoma and Multiple Myeloma Patients. BioMed Research International،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-501895
Modern Language Association (MLA)
Angelopoulou, Maria K.…[et al.]. New Insights in the Mobilization of Hematopoietic Stem Cells in Lymphoma and Multiple Myeloma Patients. BioMed Research International No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-501895
American Medical Association (AMA)
Angelopoulou, Maria K.& Tsirkinidis, Pantelis& Boutsikas, Georgios& Vassilakopoulos, Theodoros P.& Tsirigotis, Panagiotis. New Insights in the Mobilization of Hematopoietic Stem Cells in Lymphoma and Multiple Myeloma Patients. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-501895
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-501895