Lactoferrin Augmentation of the BCG Vaccine Leads to Increased Pulmonary Integrity
Joint Authors
Hwang, Shen-An
Welsh, Kerry J.
Actor, Jeffrey K.
Kruzel, Marian L.
Source
Tuberculosis Research and Treatment
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-04-28
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The goal of vaccination to prevent tuberculosis disease (TB) is to offer long-term protection to the individual and the community.
In addition, the success of any protective TB vaccine should include the ability to limit cavitary formation and disease progression.
The current BCG vaccine protects against disseminated TB disease in children by promoting development of antigenic-specific responses.
However, its efficacy is limited in preventing postprimary pulmonary disease in adults that is responsible for the majority of disease and transmission.
This paper illustrates the use of lactoferrin as an adjuvant to boost efficacy of the BCG vaccine to control organism growth and limit severe manifestation of pulmonary disease.
This resulting limitation in pathology may ultimately, limit spread of bacilli and subsequent transmission of organisms between individuals.
The current literature is reviewed, and data is presented to support molecular mechanisms underlying lactoferrin's utility as an adjuvant for the BCG vaccine.
American Psychological Association (APA)
Hwang, Shen-An& Welsh, Kerry J.& Kruzel, Marian L.& Actor, Jeffrey K.. 2011. Lactoferrin Augmentation of the BCG Vaccine Leads to Increased Pulmonary Integrity. Tuberculosis Research and Treatment،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-501926
Modern Language Association (MLA)
Hwang, Shen-An…[et al.]. Lactoferrin Augmentation of the BCG Vaccine Leads to Increased Pulmonary Integrity. Tuberculosis Research and Treatment No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-501926
American Medical Association (AMA)
Hwang, Shen-An& Welsh, Kerry J.& Kruzel, Marian L.& Actor, Jeffrey K.. Lactoferrin Augmentation of the BCG Vaccine Leads to Increased Pulmonary Integrity. Tuberculosis Research and Treatment. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-501926
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-501926