The Relationship between Carotid Atherosclerosis, Inflammatory Cytokines, and Oxidative Stress in Middle-Aged and Elderly Hemodialysis Patients

Abstract EN

Objective.

To identify the relationship between microinflammation, oxidative stress, and carotid arterial stiffness in hemodialysis patients.

Methods.

The CAS β and PWV obtained by ultrasound technology were used to assess carotid arterial stiffness.

We divided the patients into either the CAS group or the non-CAS group based on the presence or absence of CAS.

The parameters of ALB, Ca, P, TC, HDL, LDL, TG, glucose, creatinine, and hs-CRP levels were routinely tested in both groups of patients.

The levels of TNF-α, IL-6, and 8-isoprostane F2α were measured by ELISA.

Results.

A total of 42 patients were enrolled in the CAS group and 20 patients were enrolled in the non-CAS group.

No significant differences between the CAS group and the non-CAS group were observed with respect to age, dialysis duration, DBP, BUN, Cr, TC, TG, HDL, LDL, and Hb.

However, SBP , pulse pressure, and 8-isoprostane levels of the CAS group were higher than those of the non-CAS group.

The hs-CRP, TNF-α, and IL-6 levels were elevated in both groups but showed no significant differences.

Conclusions.

Maintenance of hemodialysis patients exhibits a microinflammatory state that may lead to atherosclerosis.

The roles of hypertension and oxidative stress may be more important.