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Molecular Mechanisms of Resistance to Tumour Anti-Angiogenic Strategies
Joint Authors
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-03-09
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Tumour angiogenesis, described by Folkman in the early seventies, is an essential, complex, and dynamic process necessary for the growth of all solid tumours.
Among the angiogenic factors secreted by the tumour cells, the Vascular Endothelial Growth Factor (VEGF) is one of the most important.
Most types of human cancer cells express elevated levels of this proangiogenic factor and its receptors.
New molecules, called anti-angiogenic, are developed to impair VEGF pathway and tumour vasculature.
Despite important results, the clinical benefits of anti-VEGF therapy are relatively modest and usually measured in weeks or months.
Why following anti-angiogenic therapy do some patients respond transiently and then why does tumour grow again and disease progress and which compensatory mechanisms could explain the anti-angiogenic treatment failure?
American Psychological Association (APA)
Grépin, Renaud& Pagès, Gilles. 2010. Molecular Mechanisms of Resistance to Tumour Anti-Angiogenic Strategies. Journal of Oncology،Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-501941
Modern Language Association (MLA)
Grépin, Renaud& Pagès, Gilles. Molecular Mechanisms of Resistance to Tumour Anti-Angiogenic Strategies. Journal of Oncology No. 2010 (2010), pp.1-8.
https://search.emarefa.net/detail/BIM-501941
American Medical Association (AMA)
Grépin, Renaud& Pagès, Gilles. Molecular Mechanisms of Resistance to Tumour Anti-Angiogenic Strategies. Journal of Oncology. 2010. Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-501941
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-501941