Total Phenolics and Total Flavonoids Contents and Hypnotic Effect in Mice of Ziziphus mauritiana Lam. Seed Extract

Joint Authors

Gritsanapan, Wandee
San, Aye Moh Moh
Sithisarn, Pongtip
Thongpraditchote, Suchitra

Source

Evidence-Based Complementary and Alternative Medicine

Issue

Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-4, 4 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2013-06-04

Country of Publication

Egypt

No. of Pages

4

Main Subjects

Medicine

Abstract EN

The seeds of Ziziphus mauritiana Lam.

have been traditionally used for treatment of various complications including insomnia and anxiety.

They are popularly used as sedative and hypnotic drugs in China, Korea, Myanmar, Vietnam, and other Asian countries.

However, no scientific proof on hypnotic activity of Z.

mauritiana seeds (ZMS) was reported.

In this study, the hypnotic activity of 50% ethanolic extract from ZMS was observed on the loss of righting reflex in mice using pentobarbital-induced sleep mice method.

The contents of total phenolics and total flavonoids in the extract were also determined.

The results showed that the 50% ethanolic extract from ZMS contained total phenolics 27.62±1.43 mg gallic acid equivalent (GAE)/g extract and total flavonoids 0.74±0.03 mg quercetin equivalent (QE)/g extract.

Oral administration of the extract at the dose of 200 mg/kg significantly increased the sleeping time in mice intraperitoneally administered with sodium pentobarbital (50 mg/kg body weight).

These results supported the traditional use of ZMS for the treatment of insomnia.

The seeds of Z.

mauritiana should be further developed as an alternative sedative and/or hypnotic product.

American Psychological Association (APA)

San, Aye Moh Moh& Thongpraditchote, Suchitra& Sithisarn, Pongtip& Gritsanapan, Wandee. 2013. Total Phenolics and Total Flavonoids Contents and Hypnotic Effect in Mice of Ziziphus mauritiana Lam. Seed Extract. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-501957

Modern Language Association (MLA)

San, Aye Moh Moh…[et al.]. Total Phenolics and Total Flavonoids Contents and Hypnotic Effect in Mice of Ziziphus mauritiana Lam. Seed Extract. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-4.
https://search.emarefa.net/detail/BIM-501957

American Medical Association (AMA)

San, Aye Moh Moh& Thongpraditchote, Suchitra& Sithisarn, Pongtip& Gritsanapan, Wandee. Total Phenolics and Total Flavonoids Contents and Hypnotic Effect in Mice of Ziziphus mauritiana Lam. Seed Extract. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-501957

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-501957