An Isocratic Method for Quantification of Valproic Acid and Its Related Impurities Using Ion Pair Reagent by Ultraperformance Liquid Chromatography
Joint Authors
Patel, Madhavi
Saravaia, Hitesh
Shah, Anamik
Ambasana, Mrunal
Thakkar, Rakshit
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-17
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
A selective ultraperformance liquid chromatographic (UPLC) method for the quantification of valproic acid and its known related impurities using ion pair reagent has been developed.
The method includes reversed-phase Acquity HSS T3 column with 100 mm × 2.1 mm i.d.
and 1.7 μ particle size.
The mobile phase consists of acetonitrile, 5 mM 1-hexanesulphonic acid sodium salt, flow rate is 0.6 mL/min, and UV detection is performed at 215 nm.
A system suitability test (SST) was developed to govern the quality of the separation.
The developed method has been validated further with respect to linearity, accuracy, precision, selectivity, LOD, LOQ, and Robustness.
American Psychological Association (APA)
Thakkar, Rakshit& Saravaia, Hitesh& Ambasana, Mrunal& Patel, Madhavi& Shah, Anamik. 2012. An Isocratic Method for Quantification of Valproic Acid and Its Related Impurities Using Ion Pair Reagent by Ultraperformance Liquid Chromatography. ISRN Chromatography،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-501990
Modern Language Association (MLA)
Thakkar, Rakshit…[et al.]. An Isocratic Method for Quantification of Valproic Acid and Its Related Impurities Using Ion Pair Reagent by Ultraperformance Liquid Chromatography. ISRN Chromatography No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-501990
American Medical Association (AMA)
Thakkar, Rakshit& Saravaia, Hitesh& Ambasana, Mrunal& Patel, Madhavi& Shah, Anamik. An Isocratic Method for Quantification of Valproic Acid and Its Related Impurities Using Ion Pair Reagent by Ultraperformance Liquid Chromatography. ISRN Chromatography. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-501990
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-501990
