Turning on Myogenin in Muscle : A Paradigm for Understanding Mechanisms of Tissue-Specific Gene Expression
Joint Authors
Faralli, Herve
Dilworth, F. Jeffrey
Source
Comparative and Functional Genomics
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-28
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Expression of the myogenin (Myog) gene is restricted to skeletal muscle cells where the transcriptional activator turns on a gene expression program that permits the transition from proliferating myoblasts to differentiating myotubes.
The strict temporal and spatial regulation on Myog expression in the embryo makes it an ideal gene to study the developmental regulation of tissue-specific expression.
Over the last 20 years, our knowledge of the regulation of Myog expression has evolved from the identification of the minimal promoter elements necessary for the gene to be transcribed in muscle, to a mechanistic understanding of how the proteins that bind these DNA elements work together to establish transcriptional competence.
Here we present our current understanding of the developmental regulation of gene expression gained from studies of the Myog gene.
American Psychological Association (APA)
Faralli, Herve& Dilworth, F. Jeffrey. 2012. Turning on Myogenin in Muscle : A Paradigm for Understanding Mechanisms of Tissue-Specific Gene Expression. Comparative and Functional Genomics،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-502011
Modern Language Association (MLA)
Faralli, Herve& Dilworth, F. Jeffrey. Turning on Myogenin in Muscle : A Paradigm for Understanding Mechanisms of Tissue-Specific Gene Expression. Comparative and Functional Genomics No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-502011
American Medical Association (AMA)
Faralli, Herve& Dilworth, F. Jeffrey. Turning on Myogenin in Muscle : A Paradigm for Understanding Mechanisms of Tissue-Specific Gene Expression. Comparative and Functional Genomics. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-502011
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-502011