NOP Receptor Ligands as Potential Agents for Inflammatory and Autoimmune Diseases
Joint Authors
Gavioli, Elaine Cristina
Romão, Pedro R. T.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-17
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Nociceptin/orphanin FQ (N/OFQ) is a seventeen-amino acid peptide that is the endogenous ligand of a G-protein-coupled receptor (NOP).
Various immune cells express the precursor protein and secrete N/OFQ as well as display binding sites for this peptide.
The functional capacity of NOP receptor was demonstrated in vitro and in vivo studies by the ability of N/OFQ to induce chemotaxis of immune cells, to regulate the expression of cytokines and other inflammatory mediators, and to control cellular and humoral immunity.
In this context, N/OFQ could modulate the outcome of some inflammatory diseases, such as sepsis and autoimmune pathologies by mechanisms not clearly elucidated yet.
In fact, human body fluid revealed increased levels of N/OFQ under sepsis, arthritis, and Parkinson's diagnose.
Preclinical studies pointed to the blockade of NOP receptor signaling as successful in treating these experimental conditions.
Further preclinical and clinical studies are required to investigate the potential of NOP ligands in treating inflammatory diseases.
American Psychological Association (APA)
Gavioli, Elaine Cristina& Romão, Pedro R. T.. 2011. NOP Receptor Ligands as Potential Agents for Inflammatory and Autoimmune Diseases. Journal of Amino Acids،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-502033
Modern Language Association (MLA)
Gavioli, Elaine Cristina& Romão, Pedro R. T.. NOP Receptor Ligands as Potential Agents for Inflammatory and Autoimmune Diseases. Journal of Amino Acids No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-502033
American Medical Association (AMA)
Gavioli, Elaine Cristina& Romão, Pedro R. T.. NOP Receptor Ligands as Potential Agents for Inflammatory and Autoimmune Diseases. Journal of Amino Acids. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-502033
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-502033